24134-10-9

Basic information

• Product Name: 1,2-dimethylimidazol-5-ylphenylmethanol
• Synonyms: 1,2-dimethylimidazol-5-ylphenylmethanol
• CAS NO: 24134-10-9
• Molecular Weight: 202.256
• Mol File: 24134-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-dimethylimidazol-5-ylphenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethylimidazol-5-ylphenylmethanol(24134-10-9)
• EPA Substance Registry System: 1,2-dimethylimidazol-5-ylphenylmethanol(24134-10-9)

Safety Data

• Hazardous Substances Data: 24134-10-9(Hazardous Substances Data)

Upstream product

• 1739-84-0 1,2-dimethyl-1H-imidazole 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 86051-80-1 1-methyl-5-trimethylsilylimidazol-2-yldiphenylmethanol 
• 235092-29-2 (1,2-dimethyl-1H-imidazol-5-yl)(phenyl)methanone 
• 235092-33-8 (5-benzoyl-1-methyl-1H-imidazol-2-yl)-acetic acid ethyl ester 

Relevant articles and documents

Reactions of 1,2-Dimethylimidazole, Particularly its Metallation

A re-examination of the metallation of 1,2-dimethylimidazole has shown that, after quenching of reaction mixtures with suitable reagents, single products may arise from substitution either in the 2-methyl group or in the 5-position or mixtures of both products may arise, depending on the metallating reagent, solvent, and reaction conditions. 1,2-Dimethylimidazol-5-yl-lithium was prepared by reaction of 1,2-dimethyl-5-trimethylstannylimidazole (13) with n-butyl-lithium in tetrahydrofuran at -100 deg C.The corresponding 5-trimethylsilyl compounds (12) was metallated by n-butyl-lithium exclusively in the 2-methyl group. 1,2-Dimethylimidazol-5-yl-lithium was shown to undergo transmetallation reactions at temperatures higher than -100 deg C.An improved procedure is given for the synthesis of 1,2-dimethylimidazole-5-carbaldehyde via hydroxymethylation of 1,2-dimethylimidazole and oxidation of the 5-hydroxymethyl group with nitric acid.