24137-11-9Relevant academic research and scientific papers
A Five-Step Cascade for the Modular and Regiodefined Synthesis of Naphth[2,1-d]oxazoles
Dinda, Bidyut Kumar,Basak, Shyam,Ghosh, Bidhan,Mal, Dipakranjan
, p. 1235 - 1245 (2016)
The reaction of 3-nucleofugal phthalides with 2-amidoacrylates is shown to provide a synthesis of densely substituted naphth[2,1-d]oxazoles in good yields. It is proposed to proceed via a five-step cascade which includes phthalide annulation, demethoxycarbonylation, and heterocyclization. The methodology is free from regiochemical ambiguity of the products. In certain cases, the corresponding 2-amidonaphthoquinones are directly formed.
