241472-56-0

Upstream product

• 17937-68-7 diphenyl-divinyl-silane 
• 80-10-4 diphenylsilyl dichloride 

Downstream Products

• 1488348-38-4 bis(2-((methylsulfonyl)oxy)-ethyl)diphenylsilane 
• 1488348-40-8 bis(2-azidoethyl)diphenylsilane 
• 1488348-39-5 2-azidoethyl(2-((methylsulfonyl)oxy)ethyl)diphenylsilane 
• 1577213-73-0 2-((2-bromoethyl)diphenylsilyl)ethyl acetate 
• 1577213-75-2 2-(diphenyl(2-(((trifluoromethyl)sulfonyl)oxy)ethyl)silyl)ethylacetate 
• 1577213-38-7 C₁₆H₁₇FO₂Si 
• 1577213-40-1 2-((2-fluoroethyl)diphenylsilyl)ethyl acetate 
• 1577213-43-4 2-(hydroxydiphenylsilyl)ethyl acetate 
• 1577213-46-7 2-((2-fluoroethyl)diphenylsilyl)ethanol 
• 1577213-49-0 1-(2-((2-fluoroethyl)diphenylsilyl)ethyl)-2-nitro-1H-imidazole 
• 1577213-36-5 2-((2-hydroxyethyl)diphenylsilyl)ethyl acetate 
• 241472-71-9 2-[4-(4,4-diphenyl-[1,4]azasilinan-1-ylmethyl)-benzyl]-isoindole-1,3-dione 
• 241472-70-8 [4-(4,4-diphenyl-[1,4]azasilinan-1-ylmethyl)-benzyl]-carbamic acid benzyl ester 
• 241472-69-5 [4-(4,4-diphenyl-[1,4]azasilinan-1-ylmethyl)-benzyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Studies toward terminal (fluoroalkyl)silanes. Investigation of diethylaminosulfur trifluoride (DAST) in exchange reactions with some terminal (hydroxyalkyl)silanes

Aiming at a convenient way toward the synthesis of terminal (fluoroalkyl)silanes, the effect of (diethylamino)sulfur trifluoride (DAST) on some terminal hydroxyalkylsilanes was investigated. Reaction of DAST with a substituted (hydroxyethyl)diphenylsilane led to the formation of the desired (2-fluoroethyl)diphenylsilane in considerable amounts although the competing elimination route was still the favored mechanism. This new reaction was studied under various parameters with the best conditions yielding the substitution product in a ratio of 1:4 over the undesired elimination product. In a different approach trying to optimize the outcome of the reaction, the presence of two bulky 2,4,6-trimethoxyphenyl (TMOP) groups on the silicon atom favored the elimination route.

Synthesis of 4-silapiperidine building blocks with N-H groups using the Staudinger reaction

4-Silapiperidines are important skeletons for drug design. In this context, a novel acid-free method for the synthesis of 4-silapiperidine building blocks with N-H groups has been developed, using the Staudinger reaction as the key step. As a proof of principle, the model compounds 13 and 14 were synthesized, starting from Ph2SiCl2 and MeSi(OMe)3, respectively.

Diphenylsilyldiethylene- (DPSide-) group: A new primary amine protection

Diphenylsilydiethylene- (DPSide-) group has been developed as a new primary amine protecting group. The new protecting group exhibits novel orthogonality against other commonly used amine-protecting groups and excellent chemoselectivity for unbranched α-amino acid esters. Removal of this protecting group was effected under mild fluoride-based cleavage conditions.