241496-82-2

Basic information

• Product Name: 2-AMino-3-(4-broMobenzoyl)benzoic Acid
• Synonyms: 2-AMino-3-(4-broMobenzoyl)benzoic Acid;bromfenac sodiumImpurity 11;Bromfenac Impurity A
• CAS NO: 241496-82-2
• Molecular Formula: C₁₄H₁₀BrNO₃
• Molecular Weight: 320.1381
• Product Categories: Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 241496-82-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 535.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.612±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly)
• PKA: 4.49±0.10(Predicted)
• CAS DataBase Reference: 2-AMino-3-(4-broMobenzoyl)benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-3-(4-broMobenzoyl)benzoic Acid(241496-82-2)
• EPA Substance Registry System: 2-AMino-3-(4-broMobenzoyl)benzoic Acid(241496-82-2)

Safety Data

• Hazardous Substances Data: 241496-82-2(Hazardous Substances Data)

Usage

Uses

2-Amino-3-(4-bromobenzoyl)benzoic Acid is a metabolite of Bromfenac sodium

Upstream product

• 241825-88-7 7-(4-bromobenzoyl)indoline-2,3-dione 

Relevant articles and documents

Synthesis method of bromfenac sodium impurity standard substance 2-amino-3-(4-bromo benzoyl) benzoic acid

The invention discloses a synthesis method of a bromfenac sodium impurity standard substance 2-amino-3-(4-bromo benzoyl) benzoic acid. 7-(4-Bromobenzoyl)indoline-2,3-dione is taken as a material, the operations of decarboxylation and refining are carried out to prepare a pure product of 2-amino-3-(4-bromo benzoyl) benzoic acid, and the content of the pure product is calibrated through a conventional analysis means. The impurity preparation method provided by the invention is simple and convenient in process and short in preparation period, and calibration shows that the product content is higher than 99.0%. The bromfenac sodium impurity provided by the invention can serve as the impurity standard substance, and is applied to qualitative and quantitative researches and detection of the bromfenac sodium material and the preparation impurity.