24152-39-4

Basic information

• Product Name: 4-BUTYLPIPERIDINE
• Synonyms: 4-BUTYLPIPERIDINE;4-Butylpiperidine(HCL);4-Butylpiperidine(HCl forM);Tirofiban Impurity 4;4-BUTYLPIPERIDINE(HCL)(RS20008646)
• CAS NO: 24152-39-4
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.25386
• Product Categories: Piperidine
• Mol File: 24152-39-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 28°C (estimate)
• Boiling Point: 178.34°C (estimate)
• Flash Point: 64.226 °C
• Appearance: /
• Density: 0.8790
• Refractive Index: 1.4472
• PKA: 10.70±0.10(Predicted)
• CAS DataBase Reference: 4-BUTYLPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BUTYLPIPERIDINE(24152-39-4)
• EPA Substance Registry System: 4-BUTYLPIPERIDINE(24152-39-4)

Safety Data

• Hazardous Substances Data: 24152-39-4(Hazardous Substances Data)

Usage

Uses

4-Butylpiperidine is a reactant in the synthesis of 77-LH-28-1; a CNS penetrant and selective M1 muscarinic receptor agonist.

InChI:InChI=1/C9H19N.ClH/c1-2-3-4-9-5-7-10-8-6-9;/h9-10H,2-8H2,1H3;1H

Upstream product

• 5335-75-1 4-butylpyridine 
• 71-36-3 butan-1-ol 
• 132439-21-5 N-benzyl-4-butylidenepiperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 89656-23-5 1,2,5,6-tetrahydropyridine N'-tert-butylformamidine 
• 89656-51-9 tert-Butyl-[1-(4-butyl-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine 
• 86801-34-5 4-Butyl-4H-pyridine-1-carboxylic acid phenyl ester 
• 110-86-1 pyridine 
• 651053-81-5 phenyl 4-butylpiperidine-1-carboxylate 

Downstream Products

• 244291-78-9 4-(4-n-butylpiperidin-1-yl)butanenitrile 
• 141047-99-6 (S)-2-[(S)-1-Benzyl-2-(4-butyl-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide 
• 141047-87-2 (S)-2-[(S)-1-Benzyl-2-(4-butyl-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid 
• 110331-91-4 3-(4-butyl-piperidin-1-yl)-1-(4-propoxy-phenyl)-propan-1-one 
• 86188-10-5 [5-Amino-2-(4-butyl-piperidin-1-yl)-phenyl]-(4-chloro-phenyl)-methanone 
• 113456-88-5 [2-(4-Butyl-piperidin-1-yl)-5-nitro-phenyl]-(4-chloro-phenyl)-methanone 
• 141047-64-5 4-butylpiperidine amide of L-phenyllactic acid 

Relevant articles and documents

Efficient Solution-Phase Parallel Synthesis of 4-Substituted N-Protected Piperidines

Practical conditions for the synthesis of 4-substituted N-protected piperidines through CuCN·2LiBr-catalyzed organozinc additions to 1-acylpyridinium salts and subsequent hydrogen-transfer hydrogenation have been established. The reaction sequence is performed at room temperature and provides 4-substituted N-protected piperidines in excellent overall yields without the isolation of intermediate dihydropyridines, In those cases in which the organozinc addition results in mixtures of 2- and 4-substituted dihydropyridines, the 2-substituted isomers are efficiently scavenged with maleic anhydride and subsequently removed by a mild extractive workup with NaHCO3 (sat.). The N-acyl group can conveniently be exchanged from N-phenoxycarbonyl to N-tBoc, thus allowing orthogonal deprotection strategies. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Muscarinic agonists

Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment.

Mesogenic Esters of the 4-(Alkylpiperidino) Benzoic Acids

A number of alkyl and 4-substituted phenyl 4-(4-alkylpiperidino) benzoates have been prepared and their proprties examined.