24152-39-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Butylpiperidine is used as a reactant for the synthesis of 77-LH-28-1, a compound with potential applications in the treatment of various medical conditions. Its role in the synthesis process is crucial for the development of new drugs and therapies.
As a CNS Penetrant:
4-Butylpiperidine is used as a central nervous system penetrant, allowing it to cross the blood-brain barrier and interact with the brain's neural pathways. This property makes it a valuable component in the development of drugs targeting neurological disorders and conditions.
As a Selective M1 Muscarinic Receptor Agonist:
4-Butylpiperidine is used as a selective agonist for the M1 muscarinic receptor, a subtype of the muscarinic acetylcholine receptors. Its selective action on the M1 receptor makes it a potential candidate for the development of drugs targeting cognitive functions, as well as other conditions related to the muscarinic system.

InChI:InChI=1/C9H19N.ClH/c1-2-3-4-9-5-7-10-8-6-9;/h9-10H,2-8H2,1H3;1H

Upstream product

• 5335-75-1 4-butylpyridine 
• 71-36-3 butan-1-ol 
• 110-86-1 pyridine 
• 89656-51-9 tert-Butyl-[1-(4-butyl-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 89656-23-5 1,2,5,6-tetrahydropyridine N'-tert-butylformamidine 
• 86801-34-5 4-Butyl-4H-pyridine-1-carboxylic acid phenyl ester 
• 651053-81-5 phenyl 4-butylpiperidine-1-carboxylate 
• 132439-21-5 N-benzyl-4-butylidenepiperidine 

Downstream Products

• 110331-91-4 3-(4-butyl-piperidin-1-yl)-1-(4-propoxy-phenyl)-propan-1-one 
• 86188-10-5 [5-Amino-2-(4-butyl-piperidin-1-yl)-phenyl]-(4-chloro-phenyl)-methanone 
• 244291-78-9 4-(4-n-butylpiperidin-1-yl)butanenitrile 
• 141047-99-6 (S)-2-[(S)-1-Benzyl-2-(4-butyl-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide 
• 141047-87-2 (S)-2-[(S)-1-Benzyl-2-(4-butyl-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid 
• 113456-88-5 [2-(4-Butyl-piperidin-1-yl)-5-nitro-phenyl]-(4-chloro-phenyl)-methanone 
• 141047-64-5 4-butylpiperidine amide of L-phenyllactic acid 

Relevant academic research and scientific papers

Efficient Solution-Phase Parallel Synthesis of 4-Substituted N-Protected Piperidines

Practical conditions for the synthesis of 4-substituted N-protected piperidines through CuCN·2LiBr-catalyzed organozinc additions to 1-acylpyridinium salts and subsequent hydrogen-transfer hydrogenation have been established. The reaction sequence is performed at room temperature and provides 4-substituted N-protected piperidines in excellent overall yields without the isolation of intermediate dihydropyridines, In those cases in which the organozinc addition results in mixtures of 2- and 4-substituted dihydropyridines, the 2-substituted isomers are efficiently scavenged with maleic anhydride and subsequently removed by a mild extractive workup with NaHCO3 (sat.). The N-acyl group can conveniently be exchanged from N-phenoxycarbonyl to N-tBoc, thus allowing orthogonal deprotection strategies. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Compounds with activity on muscarinic receptors

Compounds and methods are provided for the alleviation or treatment of diseases or conditions in which modification of muscarinic m1 receptor activity has a beneficial effect. In the method, a therapeutically effective amount of a selective muscarinic m1

Muscarinic agonists

Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment.

(Benzoylphenyl)piperidines: A new class of immunomodulators

A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety as well as an amino group (or a carbamate derivative) para to the piperidine nucleus seems to be essential for activity. The depicted compounds may be considered as the first examples of a new series of immunomodulators.

Mesogenic Esters of the 4-(Alkylpiperidino) Benzoic Acids

A number of alkyl and 4-substituted phenyl 4-(4-alkylpiperidino) benzoates have been prepared and their proprties examined.