24153-13-7Relevant academic research and scientific papers
Site-selective c-h acylation of pyridinium derivatives by photoredox catalysis
Jung, Sungwoo,Lee, Hyeonyeong,Moon, Yonghoon,Jung, Hoi-Yun,Hong, Sungwoo
, p. 9891 - 9896 (2019/10/14)
A strategy for visible-light-induced site-selective C-H acylation of pyridinium salts was developed by employing N-methoxy-or N-aminopyridinium salts, offering a powerful synthetic tool for accessing highly valuable C2- A nd C4-acylated pyridines. The met
Combined Iron/Hydroxytriazole Dual Catalytic System for Site Selective Oxidation Adjacent to Azaheterocycles
Cooper, Julian C.,Luo, Chaosheng,Kameyama, Ryohei,Van Humbeck, Jeffrey F.
supporting information, p. 1243 - 1246 (2018/02/09)
This report details a new method for site-selective methylene oxidation adjacent to azaheterocycles. A dual catalysis approach, utilizing both an iron Lewis acid and an organic hydroxylamine catalyst, proved highly effective. We demonstrate that this method provides complementary selectivity to other known catalytic approaches and represents an improvement over current heterocycle-selective reactions that rely on stoichiometric activation.
Cobalt-Catalyzed α-Alkylation of Ketones with Primary Alcohols
Zhang, Guoqi,Wu, Jing,Zeng, Haisu,Zhang, Shu,Yin, Zhiwei,Zheng, Shengping
supporting information, p. 1080 - 1083 (2017/03/14)
An ionic cobalt-PNP complex is developed for the efficient α-alkylation of ketones with primary alcohols for the first time. A broad range of ketone and alcohol substrates were employed, leading to the isolation of alkylated ketones with yields up to 98%. The method was successfully applied to the greener synthesis of quinoline derivatives while using 2-aminobenzyl alcohol as an alkylating reagent.
Pd-catalyzed cross-coupling reactions of pyridine carboxylic acid chlorides with alkylzinc reagents
Iwai, Toshiyuki,Nakai, Takeo,Mihara, Masatoshi,Ito, Takatoshi,Mizuno, Takumi,Ohno, Toshinobu
scheme or table, p. 1091 - 1094 (2009/09/25)
The efficient cross-coupling reaction to afford ketones from pyridine carboxylic acid chlorides and alkylzinc reagents in the presence of Pd(phen)Cl2 is reported. In the case of chloronicotinoyl chlorides, none of Negishi cross-coupling product
Intramolecular cation-π interactions control the conformation of nonrestricted (phenylalkyl)pyridines
Richter, Isabella,Minari, Jusaku,Axe, Philip,Lowe, John P.,James, Tony D.,Sakurai, Kazuo,Bull, Steven D.,Fossey, John S.
, p. 1082 - 1084 (2008/12/20)
NOEsy and fluorescence spectroscopy reveal that conversion of conformationally flexible (phenylalkyl)pyridines into their corresponding N-methyl-pyridinium iodides results in intramolecular π-stacking. The Royal Society of Chemistry.
Intramolecular Alkylations of Aromatic Compounds, XVIII: Synthesis of 3,4-Dihydro-1'-methylspiro
Reimann, Eberhard,Speckbacher, Johann,Lotter, Hermann
, p. 385 - 393 (2007/10/02)
Refluxing the tetrahydroyridines 10 in hydrobromic acid gives the title compounds 12 stereoselectively.Their structures and configurations were confirmed by NMR spectroscopy and X-ray analysis.The tetrahydropyridines 10 were prepared from the pyridinecarbonitriles 5 and Grignard reagents 6 by standard methods.
