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1H-Imidazole-1-ethanol,a-(2,4-dichlorophenyl)-
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No Data 100 Kilogram 150 Metric Ton/Year HANGZHOU YUNUO CHEMICAL CO.,LTD Contact Supplier
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
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α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
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High quality Alpha-(2,4-Dichlorophenyl)-1H-Imidazole-1-Ethanol supplier in China
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alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
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alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
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1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
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1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol
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24155-42-8 Usage

Uses

Intermediate in the preparation of Miconazole. An impurity in the synthesis of Fenticonazole. An impurity in the synthesis of Ketoconazole.

Chemical Properties

cream-coloured to beige powder
InChI:InChI=1/C11H10Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15/h1-5,7,11,16H,6H2/t11-/m0/s1

24155-42-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (Y0000137)  Enilconazole impurity E  European Pharmacopoeia (EP) Reference Standard 24155-42-8 Y0000137 1,880.19CNY Detail
USP (1231830)  Econazole Related Compound A  United States Pharmacopeia (USP) Reference Standard 24155-42-8 1231830-15MG 14,500.98CNY Detail

24155-42-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol

1.2 Other means of identification

Product number -
Other names 1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]imidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24155-42-8 SDS

24155-42-8Synthetic route

1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone
46503-52-0

1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20℃; for 12h;98%
With potassium borohydride In methanol for 1h; Reflux;90.5%
With sodium tetrahydroborate In methanol for 2h; Reflux;88%
1H-imidazole
288-32-4

1H-imidazole

α-(chloromethyl)-2,4-dichlorobenzyl alcohol
13692-14-3

α-(chloromethyl)-2,4-dichlorobenzyl alcohol

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; alumina-supported potassium hydroxide at 45℃; for 3.5h;90%
With potassium carbonate; sodium iodide In water; butanone78.7%
With sodium In N-methyl-acetamide; methanol; water
1H-imidazole
288-32-4

1H-imidazole

2-(2,4-dichlorophenyl)oxirane
13692-15-4

2-(2,4-dichlorophenyl)oxirane

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
With pyridine In ethanol for 12h; Ring cleavage; Heating;63%
Stage #1: 1H-imidazole With sodium hydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #2: 2-(2,4-dichlorophenyl)oxirane In N,N-dimethyl-formamide at 60℃; Inert atmosphere;
57%
Stage #1: 1H-imidazole With sodium hydride In N,N-dimethyl-formamide Inert atmosphere;
Stage #2: 2-(2,4-dichlorophenyl)oxirane In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
tetra-n-butylammonium imidazolate
67035-78-3

tetra-n-butylammonium imidazolate

α-(chloromethyl)-2,4-dichlorobenzyl alcohol
13692-14-3

α-(chloromethyl)-2,4-dichlorobenzyl alcohol

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
In acetonitrile Reflux;68%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone nitrate

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone nitrate

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol for 2h;95%
tetra-n-butylammonium imidazolate
67035-78-3

tetra-n-butylammonium imidazolate

2-bromo-1-(2,4-dichlorophenyl)ethanol
53066-15-2

2-bromo-1-(2,4-dichlorophenyl)ethanol

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
In acetonitrile Reflux;40%
2,2',4'-trichloroacetophenone
4252-78-2

2,2',4'-trichloroacetophenone

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 28 percent / CH2Cl2 / 2 h / 40 °C
2: sodium borohydride
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / isopropyl alcohol / 2 h / 3 - 20 °C
2: acetonitrile / Reflux
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane
2: potassium borohydride / methanol / 1 h / Reflux
View Scheme
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / isopropyl alcohol / 2 h / 3 - 20 °C
2: acetonitrile / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide; water / 20 °C
2: sodium tetrahydroborate / methanol / 2 h / 5 - 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / 20 °C
2: sodium tetrahydroborate / methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 3 h / 20 °C
2: sodium tetrahydroborate / methanol / 3 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: sodium tetrahydroborate; methanol / 2 h / 0 °C / Reflux
View Scheme
1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 3 h / 30 °C
2.1: triethylamine / methanol / 20 °C
2.2: 4 h / 65 °C
3.1: sodium tetrahydroborate / ethanol / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: aluminum (III) chloride
2: triethylamine / methanol / 65 °C
3: sodium tetrahydroborate / ethanol / 20 °C
View Scheme
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine / chloroform / 1.5 h / 0 - 20 °C
2: potassium carbonate / 20 °C
3: sodium tetrahydroborate / methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: bromine / chloroform / 1 h / 0 - 20 °C
2: potassium carbonate / tetrahydrofuran / 3 h / 20 °C
3: sodium tetrahydroborate / methanol / 3 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: bromine / chloroform / 1 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3: sodium tetrahydroborate; methanol / 2 h / 0 °C / Reflux
View Scheme
2,2',4'-trichloroacetophenone
4252-78-2

2,2',4'-trichloroacetophenone

A

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

B

n-butyl halide

n-butyl halide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetonitrile
2: NaBH4 / ethanol
View Scheme
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide / acetonitrile; water / 3 h / 60 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.2: 60 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide / acetonitrile / 60 - 65 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

A

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

B

n-butyl halide

n-butyl halide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CHCl3 / 0 °C
2: sodium borohydride / ethanol / 4 h / Heating
View Scheme
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

A

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

B

3,4-Cl2-C6H3-SO2CH2-X, (X=Cl or Br)

3,4-Cl2-C6H3-SO2CH2-X, (X=Cl or Br)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / aq. KOH / acetonitrile / 3 h / 60 °C
2: 63 percent / pyridine / ethanol / 12 h / Heating
View Scheme
Hexanoyl chloride
142-61-0

Hexanoyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-[2,4-dichloro-β-(n-pentylcarbonyloxy)phenethyl]imidazole

1-[2,4-dichloro-β-(n-pentylcarbonyloxy)phenethyl]imidazole

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;97%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

2-bromoethyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside
16977-78-9, 85193-55-1, 86651-32-3, 86651-40-3

2-bromoethyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

1-[2-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)ethyl]-3-[2-hydroxy-(2,4-dichlorophenyl)ethyl]imidazolium bromide

1-[2-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)ethyl]-3-[2-hydroxy-(2,4-dichlorophenyl)ethyl]imidazolium bromide

Conditions
ConditionsYield
In acetonitrile at 110℃;96%
In acetonitrile at 110℃; for 24h;90%
3-Bromomethyl-7-chlorobenzothiophene
17512-61-7

3-Bromomethyl-7-chlorobenzothiophene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

sertaconazole nitrate
99592-39-9

sertaconazole nitrate

Conditions
ConditionsYield
Stage #1: 3-Bromomethyl-7-chlorobenzothiophene; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutyl-ammonium chloride; sodium hydroxide In water; toluene at 80℃; for 4h;
Stage #2: With nitric acid
95.7%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

3-chloroprop-1-ene
107-05-1

3-chloroprop-1-ene

1-[2-(2,4-dichlorophenyl)-2-(2-propenyloxy)ethyl]-1H-imidazole
35554-44-0

1-[2-(2,4-dichlorophenyl)-2-(2-propenyloxy)ethyl]-1H-imidazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With potassium hydroxide In water; dimethyl sulfoxide at 20℃; for 1h;
Stage #2: 3-chloroprop-1-ene In water; dimethyl sulfoxide at 30℃; for 3h; Solvent; Temperature;
95.6%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With potassium hydroxide In water; dimethyl sulfoxide at 20 - 35℃; for 1h;
Stage #2: 3-chloroprop-1-ene In water; dimethyl sulfoxide at 35 - 40℃; Reagent/catalyst;
68%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

n-octanoic acid chloride
111-64-8

n-octanoic acid chloride

1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-1-octanoyloxy-ethane
68571-21-1

1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-1-octanoyloxy-ethane

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;95%
n-decanoyl chloride
112-13-0

n-decanoyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-[2,4-dichloro-β-(n-nonylcarbonyloxy)phenethyl]imidazole

1-[2,4-dichloro-β-(n-nonylcarbonyloxy)phenethyl]imidazole

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;91%
acetic anhydride
108-24-7

acetic anhydride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl acetate
61258-54-6

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl acetate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 1.5h; Inert atmosphere;91%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

(±)-1-(2-azido-2-(2, 4-dichlorophenyl)ethyl)-1H-imidazole
94038-18-3

(±)-1-(2-azido-2-(2, 4-dichlorophenyl)ethyl)-1H-imidazole

Conditions
ConditionsYield
With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 0 - 20℃; for 3.25h; Inert atmosphere;87%
With diazabicycloundecane; diphenyl phosphoryl azide In tetrahydrofuran
With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide
3-(bromomethyl)benzothiophene
1196-19-6

3-(bromomethyl)benzothiophene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-(2-(benzo[b]thiophen-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
99592-24-2

1-(2-(benzo[b]thiophen-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 3-(bromomethyl)benzothiophene In toluene for 3h; Heating;
86%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 3-(bromomethyl)benzothiophene In toluene for 3h; Heating;
86%
With sodium hydride 1.) HMPT, RT; 2.) HMPT, 50 deg C, 1 h, 3.) HMPT, 0 deg C, 5 h;; Multistep reaction;
1-phenylthio-4-chloromethyl-benzene
1208-87-3

1-phenylthio-4-chloromethyl-benzene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

α-(2,4-dichlorophenyl)-β,N-imidazolylethyl 4-phenylthiobezyl ether nitrate

α-(2,4-dichlorophenyl)-β,N-imidazolylethyl 4-phenylthiobezyl ether nitrate

Conditions
ConditionsYield
Stage #1: 1-phenylthio-4-chloromethyl-benzene; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 58 - 60℃; for 13.5h;
Stage #2: With nitric acid In ethyl acetate; toluene at 25℃; for 3h;
85.1%
Stage #1: 1-phenylthio-4-chloromethyl-benzene; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With sodium hydroxide In tetrahydrofuran; water for 4.5h;
Stage #2: With nitric acid In water
82.1%
Stage #1: 1-phenylthio-4-chloromethyl-benzene; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 58℃; for 13.5h;
Stage #2: With nitric acid In ethyl acetate; toluene at 25℃; for 3h;
74.7%
Stage #1: 1-phenylthio-4-chloromethyl-benzene; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 58 - 60℃; for 13.5h;
Stage #2: With nitric acid In ethyl acetate at 25℃; for 3h;
71.4%
Nonanoyl chloride
764-85-2

Nonanoyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-[2,4-dichloro-β-(n-octylcarbonyloxy)phenethyl]imidazole

1-[2,4-dichloro-β-(n-octylcarbonyloxy)phenethyl]imidazole

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;84%
propionyl chloride
79-03-8

propionyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Propionic acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Propionic acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;83%
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-(2,4-dichloro-phenyl)-1-dodecanoyloxy-2-imidazol-1-yl-ethane
68571-23-3

1-(2,4-dichloro-phenyl)-1-dodecanoyloxy-2-imidazol-1-yl-ethane

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;82%
undecanoyl chloride
17746-05-3

undecanoyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Undecanoic acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Undecanoic acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;82%
trans-geranyl bromide
6138-90-5

trans-geranyl bromide

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-[2-(2,4-dichlorophenyl)-2-((E)-3,7-dimethylocta-2,6-dienyloxy)ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-((E)-3,7-dimethylocta-2,6-dienyloxy)ethyl]-1H-imidazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With sodium hydride In N,N-dimethyl-formamide at 40℃; for 0.5h; deprotonation;
Stage #2: trans-geranyl bromide In N,N-dimethyl-formamide at 20℃; for 0.5h; Etherification;
82%
In N-methyl-acetamide
7-chloro-3-(chloromethyl)benzo[b]thiophene

7-chloro-3-(chloromethyl)benzo[b]thiophene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

sertaconazole
99592-32-2

sertaconazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetra-(n-butyl)ammonium iodide; sodium hydroxide In water; toluene at 50℃; for 0.25h; Inert atmosphere;
Stage #2: 7-chloro-3-(chloromethyl)benzo[b]thiophene In water; toluene at 50℃; for 4h; Inert atmosphere;
82%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

2-(bromomethyl)naphthalene
3163-27-7

2-(bromomethyl)naphthalene

1-(2-(2,4-dichlorophenyl)-2-(naphthalen-1-ylmethoxy)ethyl)-1H-imidazole

1-(2-(2,4-dichlorophenyl)-2-(naphthalen-1-ylmethoxy)ethyl)-1H-imidazole

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; tetra-(n-butyl)ammonium iodide; sodium hydride at 0℃;80%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 2-(bromomethyl)naphthalene In toluene for 3h; Heating;
72%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 2-(bromomethyl)naphthalene In toluene for 3h; Heating;
72%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

2-bromomethylnaphthyl bromide
939-26-4

2-bromomethylnaphthyl bromide

1-(2-(2,4-dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)-1H-imidazole

1-(2-(2,4-dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)-1H-imidazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 2-bromomethylnaphthyl bromide In toluene for 3h; Heating;
76%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 2-bromomethylnaphthyl bromide In toluene for 3h; Heating;
76%
With sodium hydride 1.) HMPA, 20 degC - 25 degC, 1 h; 50 degC - 60 degC, 2 h; 2.) 50 degC, 20 h; Yield given. Multistep reaction;
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-chloro-1-(2,4-dichlorophenyl)-2-(1H-imidazole-1-yl)ethane
46503-49-5

1-chloro-1-(2,4-dichlorophenyl)-2-(1H-imidazole-1-yl)ethane

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 12h;74.3%
With thionyl chloride In dichloromethane
With thionyl chloride at 20℃;
butyryl chloride
141-75-3

butyryl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Butyric acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Butyric acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;74%
2,4-Dichlorobenzyl chloride
94-99-5

2,4-Dichlorobenzyl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

miconazole
22916-47-8

miconazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Substitution;
Stage #2: 2,4-Dichlorobenzyl chloride In tetrahydrofuran at 45℃; for 16h; Substitution;
73%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With sodium hydride In N,N-dimethyl-formamide Inert atmosphere;
Stage #2: 2,4-Dichlorobenzyl chloride In N,N-dimethyl-formamide at 20℃;
p-phenylbenzyl bromide
2567-29-5

p-phenylbenzyl bromide

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-[2-biphenyl-4-ylmethoxy-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
73151-17-4

1-[2-biphenyl-4-ylmethoxy-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; tetra-(n-butyl)ammonium iodide; sodium hydride at 0℃;73%
n-valeryl chloride
638-29-9

n-valeryl chloride

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Pentanoic acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Pentanoic acid 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 4h; Ambient temperature;71%
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-(2-(2,4-dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl)-1H-imidazole
119386-74-2

1-(2-(2,4-dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl)-1H-imidazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 3-Bromomethylthiophene In toluene for 3h; Heating;
71%
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutylammomium bromide; sodium hydroxide In toluene at 85℃; for 0.5h;
Stage #2: 3-Bromomethylthiophene In toluene for 3h; Heating;
71%
1,3-Dichloro-2-chloromethyl-benzene
2014-83-7

1,3-Dichloro-2-chloromethyl-benzene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

isoconazole

isoconazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With sodium hydride In 1,4-dioxane; mineral oil at 20℃; for 1h; Inert atmosphere; Reflux;
Stage #2: 1,3-Dichloro-2-chloromethyl-benzene In 1,4-dioxane; mineral oil Inert atmosphere; Reflux;
70%
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

4-bromobenzyl halide

4-bromobenzyl halide

1-(2-((4-bromobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

1-(2-((4-bromobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With sodium hydride In N,N-dimethyl-formamide at -5 - 20℃; for 1.5h; Inert atmosphere;
Stage #2: 4-bromobenzyl halide In N,N-dimethyl-formamide at 0 - 20℃; for 1h; Inert atmosphere;
68.4%

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