24170-23-8Relevant academic research and scientific papers
Synthesis and antiaggregator activity of some new derivatives of 4H-benzopyran-4-one
Goeker, H.,Ayhan, G.,Tuncbilek, M.,Ertan, R.,Leoncini, G.,et al.
, p. 561 - 568 (2007/10/02)
A series of 2--4H-1-benzopyran-4-one analogues 7a-7e was synthesized by the reaction with 3',4'-diaminoflavone and aliphatic carboxylic acids. 3',4'-Diaminoflavone 6 was prepared via the reduction of 2-(4-amino-3-nitrophenyl)-4H-1-benzopyran-4-one 5a.The compounds 7a-e and 14a-f were tested in vitro for their inhibitory activities against human platelet aggregation induced by collagen, ADP and A23187.The compound with a COOR group as a side chain, 2-(2-akyloxycarbonyl-2,3-dihydro-1,4-benzodioxin -6-yl)-4H-1-benzopyran-4-one 14a-f, haspotent activity, and so compound 13 was also prepared as an analogue of series 14 and tested for its antiaggregator activity. 4H-1-benzopyran-4-one/ benzodioxane/ benzimidazole/ human platelet/ aggregation
DERIVATIVES OF 5(6)-BENZIMIDAZOLECARBOXYLIC ACID
Sklyarova, I. V.,Garabadzhiu, A. V.,Ginzburg, O. F.
, p. 578 - 582 (2007/10/02)
2-Aryl-5(6)-benzimidazolecarboxamides containing a 3-dimethylaminopropyl or 5-carboxypentyl group in the carboxamide fragment were synthesized by the condensation of the methoxyethylimidic esters of aromatic acids with o-diamines.
Syntheses and anthelmintic activity of alkyl 5(6)-(substituted-carbamoyl)- and 5(6)-(disubstituted-carbamoyl)benzimidazole-2-carbamates and related compounds
Kumar,Seth,Bhaduri,Visen,Misra,Gupta,Fatima,Katiyar,Chatterjee,Sen
, p. 1083 - 1089 (2007/10/02)
A number of alkyl 5(6)-(sustituted-carbamoyl)- and 5(6)-(disubstituted-carbamoyl)benzimidazole-2-carbamates and related compounds have been synthesized, and their anthelmintic activity against various intestinal helminths of experimental animals have been evaluated. A large percentage of the compounds synthesized showed noteworthy activity against Ancylostoma ceylanicum and at higher doses against Hymenolepsis nana infections. Compared to the alkyl 5(6)-(substituted-carbamoyl)benzimidazole-2-carbamates, the disubstituted carbamoyl analogues were found to exhibit better anthelmintic activity. The most active compound of the series, namely, methyl 5(6)-[(N-2- pyridylpiperazino)carbamoyl]benzimidazole-2-carbamate (90), has been screened against intestinal helminths in higher animals and as a micro- and macrofilaricidal agent. Compound 90 has been identified as a broad-spectrum anthelmintic agent. Compound 90 has been identified as a broad-spectrum anthelmintic in view of its efficacy against A. ceylanicum (hamsters and dogs), H. nana (rats), Nippostrongylus brasiliensis (rats), Syphacia obvelata (mice), A. tubaeformis (cat), Toxocara spp. (cat), and Litomososoides carinii (cotton rat).
