241803-78-1

Basic information

• Product Name: 1,8-Dihydroxy-10-(4-phenylpentanoyl)anthracen-9(10H)-one
• CAS NO: 241803-78-1
• Molecular Formula: C₂₅H₂₂O₄
• Molecular Weight: 386.45169
• Mol File: 241803-78-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,8-Dihydroxy-10-(4-phenylpentanoyl)anthracen-9(10H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Dihydroxy-10-(4-phenylpentanoyl)anthracen-9(10H)-one(241803-78-1)
• EPA Substance Registry System: 1,8-Dihydroxy-10-(4-phenylpentanoyl)anthracen-9(10H)-one(241803-78-1)

Safety Data

• Hazardous Substances Data: 241803-78-1(Hazardous Substances Data)

Upstream product

• 28591-12-0 (R,S)-4-phenylvaleryl chloride 
• 1143-38-0 1,8-dihydroxy-9(10H)-anthracenone 

Relevant articles and documents

10-Phenylbutyryl-substituted anthracenones as inhibitors of keratinocyte growth and LTB4 biosynthesis

A recent observation that phenylbutyryl anthracenone 2, an analogue of the antipsoriatic anthralin, is a potent inhibitor of leukotriene B4 (LTB4) biosynthesis has prompted a search of other anthracenones with improved antiproliferative activity. In that direction, a limited number of analogues related to 2 have been prepared and evaluated in the HaCaT keratinocytes proliferation and in the polymorphonuclear leukocyte LTB4 assay. The 4-methoxy analogue 2a and the side chain methylated 2l retain the full inhibitory activity of 1 against LTB4 biosynthesis while their antiproliferative activity is markedly enhanced and comparable to that of the antipsoriatic anthralin. In contrast to anthralin, cytotoxic effects against cell membranes are strongly reduced as documented by the LDH activity released from cytoplasm of keratinocytes.