24181-66-6

Upstream product

• 64361-54-2 dehydrobicuculline 
• 494-55-3 N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline 
• 71622-48-5 C₂₀H₁₅NO₆ 
• 84229-91-4 7,8,6',8'-tetrahydro-6H-(7'rN)-spiro[[1,3]dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxole]-6't,8'c-diol 
• 64395-08-0 8-oxo-6,8-dihydro-furo[3',4':3,4]benzo[1,2-d][1,3]dioxole-6-carboxylic acid (2-benzo[1,3]dioxol-5-yl-ethyl)-methyl-amide 
• 71622-64-5 8-bromo-8H-indeno[4,5-d][1,3]dioxole-6,7-dione 
• 62-31-7 dopamine hydrochloride 
• 50506-19-9 2'-formyl-8t-hydroxy-6',7'-bis-methoxycarbonyloxy-3',4'-dihydro-8H,2'H-(7rN)-spiro[indeno[4,5-d][1,3]dioxole-7,1'-isoquinolin]-6-one 
• 50506-20-2 6-formyl-8't-hydroxy-7,8-dihydro-6H,8'H-(7'rN)-spiro[[1,3]dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxol]-6'-one 
• 64361-52-0 8't-hydroxy-7,8-dihydro-6H,8'H-(7'rN)-spiro[[1,3]dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxol]-6'-one 
• 99132-03-3 C₂₀H₁₅NO₆ 
• 99132-04-4 C₂₁H₁₉NO₇ 
• 96860-74-1 Protoberberine 
• 75267-17-3 5-Formyl-benzo[1,3]dioxole-4-carboxylic acid ethyl ester 

Downstream Products

• 24181-64-4 severzinine 
• 24181-64-4 (+/-)-sewercinine 

Relevant academic research and scientific papers

γ-Alkoxylactones as Autounmasking Synthons for a One-step Construction of 1,3-Oxygenated Cyclopentanes. Synthesis of Fredericamycin A Core and Spirobenzylisoquinoline Alkaloids

Reaction of γ-alkoxyphthalide 7a with 3-indenyllithium leads to fredericamycin A core compound 5, whereas condensation of methylenedioxyphthalide 7b or 8 with lithiated N-methyltetrahydroisoquinoline-BF3 complex 9 affords spirobenzylisoquinoline alkaloids raddeanine 12, corydaine 13 and yenhusomidine 13.

A NOVEL AND HIGHLY STEREOSELECTIVE SYNTHESIS OF (+/-)-SIBIRICINE

A novel and stereoselective synthesis of (+/-)-sibiricine (1), a spirobenzylisoquinoline alkaloid, from the corresponding protoberberine (3) was developed using photo-oxygenation and photo-isomerization.

A TOTAL SYNTHESIS OF (+/-)-CORYDAINE FROM COPTISINE

Regioselective protection of C8-hydroxy of the spiro-diol (6b) derived from coptisine (1b), followed by oxidation of C13-hydroxy afforded the keto-oxazolidine (8b) which was treated with sodium cyanoborohydride to provide (+/-)-corydaine (5b) in an excellent yield.