24188-73-6

Basic information

• Product Name: 5-chloroisoquinolin-1(2H)-one
• Synonyms: 5-chloroisoquinolin-1(2H)-one;5-chloro-1(2H)-Isoquinolinone;5-chloro-1,2-dihydroisoquinolin-1-one
• CAS NO: 24188-73-6
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.60304
• Mol File: 24188-73-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 427.061 °C at 760 mmHg
• Flash Point: 212.079 °C
• Appearance: /
• Density: 1.34 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.87±0.20(Predicted)
• CAS DataBase Reference: 5-chloroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloroisoquinolin-1(2H)-one(24188-73-6)
• EPA Substance Registry System: 5-chloroisoquinolin-1(2H)-one(24188-73-6)

Safety Data

• Hazardous Substances Data: 24188-73-6(Hazardous Substances Data)

Usage

General Description

5-chloroisoquinolin-1(2H)-one is a chemical compound with the molecular formula C9H5ClNO. It is an isoquinolinone derivative, which is a class of organic compounds that are often used in pharmaceuticals. This particular compound contains a chlorine atom, which gives it its unique properties. Its structure and properties make it suitable for use in various chemical and pharmaceutical applications, including as a building block for the synthesis of other organic compounds. Its potential uses and applications make 5-chloroisoquinolin-1(2H)-one an important compound in the field of organic chemistry.

Upstream product

• 5430-45-5 5-chloro-isoquinoline 
• 70810-25-2 5-chloroisoquinoline 2-oxide 
• 1409965-21-4 (E)-3-(2-chlorophenyl)acryloyl azide 

Downstream Products

• 1409965-24-7 5-chloro-4-methoxyisoquinolin-1-(2H)-one 

Relevant articles and documents

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula (I) wherein A, R2, R3, R', B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.