24192-86-7Relevant academic research and scientific papers
Heterocyclizations towards 2-arylbenzimidazoles via intermolecular coupling of 2-nitroanilines and aryl aldehydes
Kim, Byeong Hyo,Han, Rongbi,Han, Tae Hee,Jun, Young Moo,Baik, Woonphil,Lee, Byung Min
, p. 5 - 10 (2002)
The reductive intermolecular coupling/heterocyclization reaction between 2-nitroaniline and aromatic aldehydes towards 2-substituted and 1,2-disubstituted benzimidazoles was accomplished in the presence of 2-bromo-2-nitropropane/Zn in a MeOH/CH2/sub
Suzuki-miyaura cross-coupling of unprotected, nitrogen-rich heterocycles: Substrate scope and mechanistic investigation
Duefert, M. Alexander,Billingsley, Kelvin L.,Buchwald, Stephen L.
supporting information, p. 12877 - 12885 (2013/09/23)
The Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles using precatalysts P1 or P2 is reported. The procedure allows for the reaction of variously substituted indazole, benzimidazole, pyrazole, indole, oxindole, and azaindole halides under mild conditions in good to excellent yields. Additionally, the mechanism behind the inhibitory effect of unprotected azoles on Pd-catalyzed cross-coupling reactions is described based on evidence gained through experimental, crystallographic, and theoretical investigations.
Microwave-assisted one-pot synthesis of 2-(substituted phenyl)-1H- benzimidazole derivatives
Navarrete-Vazquez, Gabriel,Moreno-Diaz, Hermenegilda,Estrada-Soto, Samuel,Torres-Piedra, Mariana,Leon-Rivera, Ismael,Tlahuext, Hugo,Munoz-Muniz, Omar,Torres-Gomez, Hector
, p. 2815 - 2825 (2008/02/11)
A series of 2-(substituted phenyl)-1H-benzimidazole derivatives with various 5-and 6-position substituents (-H, -CH3, -CF3) were synthesized via microwave irradiation using a short synthetic route and Na2S2O5 as oxidant. This simple, fast, and efficient p
Design, microwave-assisted synthesis, and spasmolytic activity of 2-(alkyloxyaryl)-1H-benzimidazole derivatives as constrained stilbene bioisosteres
Navarrete-Vazquez, Gabriel,Moreno-Diaz, Hermenegilda,Aguirre-Crespo, Francisco,Leon-Rivera, Ismael,Villalobos-Molina, Rafael,Munoz-Muniz, Omar,Estrada-Soto, Samuel
, p. 4169 - 4173 (2007/10/03)
A simple, fast, and efficient method for the preparation of several 2-(alkyloxyaryl)-1H-benzimidazole derivatives is reported. Compounds were synthesized through a rapid one-pot three component reaction via microwave irradiation, starting from commerciall
Indium-mediated reductive intermolecular coupling reaction of 2-nitroaniline with aromatic aldehydes to benzimidazoles
Kim, Byeong Hyo,Han, Rongbi,Kim, Ji Sook,Jun, Young Moo,Baik, Woonphil,Lee, Byung Min
, p. 41 - 54 (2007/10/03)
2-Nitroaniline and aromatic aldehydes were coupled to give benzimidazoles in high yields in the presence of 2-bromo-2-nitropropane and indium at room temperature.
