24194-10-3

Usage

Classification

Derivative of amphetamine, designer drug 4-MTA is a modified version of the amphetamine class of drugs and is created for recreational purposes.

Usage

Recreational psychoactive substance 4-MTA is often sold and used for its psychoactive effects during social or recreational settings.

Effects

Stimulant and entactogenic 4-MTA is known for producing stimulating and empathogen-like effects, similar to those of amphetamines and MDMA.

Mechanism of action

Releasing agent of serotonin, dopamine, and norepinephrine 4-MTA is believed to act by increasing the release of these neurotransmitters, leading to its effects.

Psychological effects

Euphoria, increased energy, heightened sensory perception The release of neurotransmitters results in positive psychological experiences for users.

Health risks

Cardiovascular problems, hyperthermia, psychiatric disturbances The use of 4-MTA can lead to serious health issues, including problems with the heart, body temperature regulation, and mental health.

Potential for abuse

High Due to its psychoactive effects, 4-MTA has a high potential for abuse and dependency.

Regulation

Heavily regulated in many countries To mitigate the risks associated with 4-MTA, its use and distribution are controlled in various jurisdictions around the world.

Upstream product

• 151-56-4 ethyleneimine 
• 106-45-6 para-thiocresol 
• 2576-47-8 2-bromoethylamine hydrobromide 

Downstream Products

• 96991-46-7 N-<2-(4-methylphenyl)-thioethyl>-aminoacetic acid 
• 56216-07-0 2-p-Tolylsulfinylaethylamin 
• 13512-26-0 N-(2-Tosyl-aethyl)-carbaminsaeure-aethylester 
• 13493-56-6 N-Nitroso-N-(2-(toluol-4-sulfonyl)-aethyl)-urethan 
• 13493-60-2 2--acetaldehyd-triphenyl-phosphazin 
• 1186400-98-5 benzyl (2-(p-tolylthio)ethyl)carbamate 
• 1186400-72-5 benzyl 7-methyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 
• 96991-48-9 3-<2-(4-methylphenyl)-thioethyl>-sydnone 

Relevant academic research and scientific papers

Synthesis of 2,3,4,5-Tetrahydrobenzo[1,4]thiazepines via N-Acyliminium Cyclization

We report an efficient and scalable synthesis of 7-methoxy-2,3,4,5-tetrahydrobenzo[1,4]thiazepine, the core structure of biologically active molecules like JTV-519 and S107. This synthetic route, starting with 4-methoxythiophenol and proceeding via acyliminum cyclization, gives the target product in four steps and 68% overall yield and is a substantial improvement over previously published processes. Nine additional examples of tetrahydrobenzo[1,4]thiazepine synthesis via acyliminium ring closure are also presented.

2-(Arylthio)ethanamines and &α-(Arylthio)propionamides with Antidepressant Activity

Reaction of aziridine with thiophenols affords 2-arylthioethanamines; with 2-methylaziridine, ring opening occurs regiospecifically to provide 1-arylthio-2-propanamines.The structure of one member of this group, 1-(4-chlorophenylthio)-2-propanamine (7), has been proved by other unambiguous syntheses. 7 and isomer 12 arise from the alkylation of 4-chlorothiophenol with 2-chloropropylamine as well as from the displacement of the tosyl group in 1-(4-chlorophenylthio)-2-tosyloxypropane (13).Alkylation of 4-chlorothiophenol with α-chloropropionamide affords 11 which leads to 12 on LAH reduction.Ethanamines and propanamines are converted into guanidines, amides, ureas and thioureas.Many arylthioethanamines, e.g. 7, 22, 28, 38 and 39 (as HCl salts) and α-arylthiopropionamides, e.g. 11, 86, 91, 93 and 96 exhibit good activity in the DOPA potentiation and reserpine antagonism tests.Among these, 7 HCl is the most potent and does not inhibit rat brain MAO activity.In clinical trials, C 2998-Go compares favourably with imipramine.