24202-75-3Relevant academic research and scientific papers
High-yield synthesis method of methyl 4-aminonicotinate
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Paragraph 0024; 0028-0029; 0033; 0037-0038; 0042; 0046-0047, (2021/09/08)
The invention discloses a high-yield synthesis method of methyl 4-aminonicotinate, which comprises the following steps: by taking 3, 4-dipicolinic acid as a raw material, carrying out intramolecular dehydration substitution, ammonia ammonification, improved NBS Hofmann rearrangement and hydrolysis to obtain the methyl 4-aminonicotinate. The synthesis method disclosed by the invention is simpler to operate, mild in reaction condition and higher in total yield, and has an extremely high application value.
PYRIDAZINES CONDENSED WITH A HETERO RING, II. PYRIDO AMINOPYRIDAZINES, I. SEPARATION AND STRUCTURE DETERMINATION OF THE ISOMERIC MONOCHLORO COMPOUNDS OBTAINED BY HYDROLYSIS OF 1,4-DICHLOROPYRIDOPYRIDAZINE
Koermendy, K.,Kovacs, T.,Ruff, F.,Koevesdi, I.
, p. 487 - 500 (2007/10/02)
The separation of the mixture of isomers 2 and 3, obtained by hydrolysis of 1,4-dichloropyrido pyridazine, was accomplished and the structures of the isomers (2: 1-Cl; 3:4-Cl) were verified by synthesis.Aminolysis of 2 and 3 yielded the hydroxy-ethylamino derivatives 4 and 5; a mixture of these compounds can also be synthesized from 2-tosyloxyethylcinchomeronic imide (20 -> 4, 5) in a good yield (84percent).
