242129-43-7Relevant academic research and scientific papers
Reaction of an introverted carboxylic acid with carbodiimide
Iwasawa, Tetsuo,Wash, Paul,Gibson, Christoph,Rebek Jr., Julius
, p. 6506 - 6511 (2007)
The reaction of carboxylic acids with carbodiimides is reviewed, and an 'introverted' carboxylic acid is proposed as a means of trapping reactive intermediates along the reaction pathway. The introverted acid is a cavitand with the carboxylic function directed toward the floor of the cavity. Its reaction with diisopropyl carbodiimide gives a covalent adduct that is either the elusive O-acylisourea or the commonly encountered N-acylurea.
