24214-72-0

Basic information

• Product Name: Cyclopentylhydrazine hydrochloride
• Synonyms: 1-CYCLOPENTYHYDRAZINE HYDROCHLORIDE;1-CYCLOPENTYLHYDRAZINE HYDROCHLORIDE;CYCLOPENTYL HYDRAZINE HYDROCHLORIDE;CyclopentylhydrazineHCl;Hydrazinocyclopentane hydrochloride;1-CYCLOPENTYLHYDRAZINE HCL;cyclopentylhydrazine, HCl salt;cyclopentyl-hydrazinhydrochloride
• CAS NO: 24214-72-0
• Molecular Formula: C₅H₁₂N₂*ClH
• Molecular Weight: 136.62
• Product Categories: Ring Systems
• Mol File: 24214-72-0.mol

Chemical Properties

• Melting Point: 131-132 °C
• Boiling Point: 189.7 °C at 760 mmHg
• Flash Point: 76.1 °C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 0.562mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Cyclopentylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentylhydrazine hydrochloride(24214-72-0)
• EPA Substance Registry System: Cyclopentylhydrazine hydrochloride(24214-72-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 24214-72-0(Hazardous Substances Data)

Usage

Uses

Cyclopentylhydrazine Hydrochloride

InChI:InChI=1S/C5H12N2.ClH/c6-7-5-3-1-2-4-5;/h5,7H,1-4,6H2;1H

Upstream product

• 120-92-3 cyclopentanone 
• 287729-05-9 N-cyclopentyl-N-tert-butyloxycarbonylaminophthalimide 
• 96-41-3 Cyclopentanol 
• 79201-39-1 tert-butyl 2-cyclopentylidenehydrazine carboxylate 
• 259870-74-1 tert-butyl 1-cyclopentylhydrazinecarboxylate 
• 646071-31-0 tert-butyl 2-cyclopentylhydrazinecarboxylate 

Downstream Products

• 30241-37-3 1-cyclopentyl-3-methyl-1H-pyrazol-5-amine 
• 30929-67-0 5-amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile 
• 89169-57-3 6-Methoxy-1,2,3,4-tetrahydrocyclopentaindole 
• 1426534-38-4 C₂₁H₂₄N₂O 
• 158001-01-5 1-cyclopentyl-3-phenylmethyl-5-amino-1H-pyrazole-4-carbonitrile 
• 162141-77-7 1-Cyclopentyl-3-ethyl-6-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 

Relevant articles and documents

Decarboxylative hydrazination of unactivated carboxylic acids by cerium photocatalysis

We report the cerium photocatalyzed radical decarboxylative hydrazination of carboxylic acids with di-tert-butylazodicarboxylate (DBAD). The operationally simple protocol provides rapid access to synthetically useful hydrazine derivatives and overcomes current scope limitations in the photoredox-catalyzed decarboxylation of carboxylic acids.

PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PDE9 INHIBITORS

A compound of the general formula (I) wherein R1 is selected from the group consisting of phenyl unsubstituted or substituted with 1 to 3 substituents selected from F, Cl, Br, I, CN, -O-C1-C3-alkyl, fluorinated -O-C1-C3-alkyl, -(CH2)mOH and 5-membered heterocyclic group with 1 or 2 heteroatoms selected from N, O and S; and 6- or 10-membered heteroaryl with 1 to 3 heteroatoms selected from O, N and S; R2 and R3 independently of each other represent H atom or straight or branched C1-C3 alkyl; R4 is selected from the group consisting of 4- to 6- membered cycloalkyl, wherein one of carbon atoms can be replaced by O atom, and which is unsubstituted or substituted with one or two halogen atoms,and straight or branched C1-C4 alkyl; Q represents a bond or C1-C3-alkylene, which can be optionally substituted by one to three C1-C3-alkyls; X is selected from the group consisting of O, NR5, and S(O)p; R5 represents H atom or C1-C3alkyl; m is 1, 2 or 3; p is 0, 1 or 2; and salts thereof, for use as a medicament, in particular for treating cognitive function disorders and neurodegenerative diseases.

Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

FUSED HETEROCYCLIC COMPOUNDS

Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Synthesis, biological evaluation, and structural studies on N1 and C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands

A series of N1 and C5 substituted cycloalkyl and C5 4-methylphenyl analogues of the N-(piperidin-1-yl)-4-methyl-1H-pyrazole-3-carboxamide class of cannabinoid ligands were synthesized. The analogues were evaluated for CB1 and CB2 receptor binding affinities and receptor subtype selectivity. The effects of pyrazole substitution on ligand conformation and as such receptor affinities was not readily apparent; therefore, the geometries of the N1 and C5 substituents relative to the pyrazole ring were studied using high field NMR spectroscopy and systematic molecular mechanics geometry searches. An analysis of the relative ring geometries and functional group orientations provides new insight into the structural requirements of the CB1 and CB2 ligand binding pocket.

PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease

The invention provides compounds of Formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein A, P, J, x, and R10 are as defined herein; pharmaceutical compositions thereof; and methods of using the pharmaceutical compositions for the treatment of diseases, including, diabetes, including type 1 and type 2 diabetes, hyperglycemia, dyslipidemia, impaired glucose tolerance, metabolic syndrome, and/or cardiovascular disease.

N-tert-butoxycarbonylaminophthalimide, a versatile reagent for the conversion of alcohols into alkylated tert-butylcarbazates or hydrazines via the Mitsunobu protocol

An efficient two-step method has been developed for the conversion of alcohols to substituted hydrazines. The use of N-tert- butoxycarbonylaminophthalimide as an acid partner in Mitsunobu reactions with a variety of alcohols permits the synthesis of the corresponding monoalkylated tert-butylcarbazates and hydrazines.

6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof

Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by reacting a 5-amino-1H-pyrazole-4-carbonitrile with a heterocyclylcarboxamidine, followed by diazotization and hydrolysis of the resulting 4-amino-6-heterocyclyl-pyrazolo[3,4-d]pyrimidine.