24214-73-1

Basic information

• Product Name: CYCLOHEXYLHYDRAZINE HYDROCHLORIDE
• Synonyms: CYCLOHEXYLHYDRAZINE HYDROCHLORIDE;1-CYCLOHEXYLHYDRAZINE HYDROCHLORIDE;CyclohexylhydrazineHCl;Hydrazinocyclohexane hydrochloride;Hydrazine, cyclohexyl-,hydrochloride (1:1);Cyclohexylhydrazine hydrochloride 98%;Cyclohexylhydrazine hydrochloride≥ 98%(Titration);Cyclohexylhydrazine monohydrochloride
• CAS NO: 24214-73-1
• Molecular Formula: C₆H₁₄N₂*ClH
• Molecular Weight: 150.65
• Product Categories: Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 24214-73-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 110-114 °C(lit.)
• Boiling Point: 210.9 °C at 760 mmHg
• Flash Point: 91.7 °C
• Appearance: White/Crystalline Powder
• Vapor Pressure: 0.188mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility: almost transparency
• CAS DataBase Reference: CYCLOHEXYLHYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYLHYDRAZINE HYDROCHLORIDE(24214-73-1)
• EPA Substance Registry System: CYCLOHEXYLHYDRAZINE HYDROCHLORIDE(24214-73-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 24214-73-1(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow powder,crystals or

InChI:InChI=1/C6H14N2.ClH/c7-8-6-4-2-1-3-5-6;/h6,8H,1-5,7H2;1H

Upstream product

• 60295-11-6 tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate 
• 108-94-1 cyclohexanone 
• 931-51-1 cyclohexylmagnesiumchloride 
• 60295-21-8 N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester 

Downstream Products

• 680187-00-2 1-(cyclohexyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 680187-17-1 1,5-dicyclohexyl-4-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 910480-79-4 1-cyclohexyl-5-pyridin-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 958462-25-4 N-[2-(1-cyclohexyl-5-hydroxy-1H-pyrazol-4-yl)ethyl]benzamide 
• 36210-76-1 2-cyclohexyl-5-methyl-2,4-dihydro-pyrazol-3-one 
• 52867-47-7 2-cyclohexyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester 
• 6498-34-6 cyclohexylhydrazine 
• 849239-17-4 ethyl 1-cyclohexyl-5-(4-benzyloxyphenyl)-1H-pyrazole-3-carboxylate 
• 21254-04-6 5-amino-1-cyclohexyl-1H-pyrazol-4-carbonitrile 
• 346441-11-0 1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester 
• 21253-62-3 ethyl 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylate 
• 1225387-06-3 1-(1-cyclohexyl-3-(2-methoxy-2-oxoethyl)-4-phenyl-1H-pyrazol-5-yl)-2-methoxy-2-oxoethyl benzoate 
• 1465766-49-7 1-cyclohexyl-3-methyl-5-phenyl-1H-1,2,4-triazole-d5 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION

Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.

Reactions of grignard reagents with nitrous oxide

The chemical activation of nitrous oxide (N2O) can be achieved by organocalcium, organosodium, and organolithium compounds. Grignard reagents, on the other hand, are believed to be inert. We demonstrate that this generalization is not correct. Some aliphatic Grignard reagents undergo a rapid conversion when subjected to an atmosphere of N2O. Hydrazones are the main reaction products.