2423-13-4

Basic information

• Product Name: TEAL
• Synonyms: (Z,Z,Z)-9,12,15-Octadecatrienal;(9Z,12Z,15Z)-9,12,15-Octadecatrienal;Linolenyl aldehyde
• CAS NO: 2423-13-4
• Molecular Formula: C₁₈H₃₀O
• Molecular Weight: 262.43
• Mol File: 2423-13-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TEAL(CAS DataBase Reference)
• NIST Chemistry Reference: TEAL(2423-13-4)
• EPA Substance Registry System: TEAL(2423-13-4)

Safety Data

• Hazardous Substances Data: 2423-13-4(Hazardous Substances Data)

Usage

General Description

TEAL, or triethylaluminum, is a highly flammable and pyrophoric compound commonly used as a cocatalyst in the production of polyethylene and polypropylene plastics. It is also used as a catalyst in the production of silicone rubber and as a reagent in organic synthesis. TEAL is a colorless liquid with a pungent odor and is highly reactive with water and air, making it necessary to handle with extreme caution. It can react violently with water or moisture in the air, releasing flammable gases. TEAL poses significant health risks if inhaled or comes into contact with skin, causing irritation and potential damage to the respiratory system. Due to its hazardous nature, TEAL is carefully regulated and handled under strict safety protocols in industrial settings.

Upstream product

• 102179-99-7 nonadeca-10c,13c,16c-triene-1,2-diol 
• 506-44-5 linolenyl alcohol 
• 463-40-1 (9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid 
• 102456-41-7 1-acetoxy-nonadeca-10c,13c,16c-trien-2-one 
• 59044-29-0 cis,cis,cis-9,12,15-octadecatrienoyl chloride 
• 301-00-8 methyl linolenate 

Relevant articles and documents

Sex pheromone of tomato fruit borer, Neoleucinodes elegantalis

Five candidate pheromone components were identified by analyzing pheromone gland extracts by gas chromatography (GC), coupled GC-electro-antennographic detection (EAD), and coupled GC-mass spectrometry (MS): (E)-11-hexadecenol(E11-16: OH), (Z)-11-hexadecenol(Z11-16: OH), (E)-11-hexadecenal, (E)-11-hexadecenyl acetate, and (Z)-3,(Z)-6,(Z)-9-tricosatriene (Z3,Z6,Z9-23: Hy). In electroantennogram (EAG) recordings, synthetic E11-16: OH elicited stronger antennal responses at low doses than other candidate pheromone components. Field tests demonstrated that synthetic E11-16: OH as a trap bait was effective in attracting males, whereas addition of Z11-16: OH inhibited the males' response. Z3,Z6,Z9-23 : Hy strongly enhanced attractiveness of E11-16: OH, but was not attractive by itself. A pheromone blend with synergistic behavioral activity of an alcohol (E11- 16: OH) and hydrocarbon (Z3,Z6,Z9-23: Hy) component is most unusual in the Lepidoptera. The synthetic two-component pheromone is approximately 60 times more attractive than the female-produced blend and might facilitate the control of this pest.

Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, in Vitro and in Vivo Investigations of Jamunones

Twenty-three natural jamunone analogues along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the methyl group on chromanone affected the selectivity of molecules against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (JM) was screened as the most effective anti-triple-negative breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

ALKENYL SUBSTITUTED 2,5-PIPERAZINEDIONES AND THEIR USE IN COMPOSITIONS FOR DELIVERING AN AGENT TO A SUBJECT OR CELL

Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.