24237-31-8

Upstream product

• 3937-16-4 2-(2,3,4-trimethoxyphenyl)ethylamine 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 118474-94-5 (E)-1-nitro-2-(2',3',4'-trimethoxyphenyl)ethene 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 111427-23-7 N-<2-(3,4-dimethoxyphenyl)acetyl>-2-thiazolidine-2-thione 

Downstream Products

• 74904-59-9 1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline 
• 187156-50-9 14-(3,4-dimethoxyphenyl)-3-acetoxy-2,10,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 149355-75-9 14-(3,4-dimethoxyphenyl)-3-hydroxy-2,10,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4’,3’:4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 919082-31-8 ethyl 1-(3,4-dimethoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-7,8,9-trimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate 
• 919082-44-3 14-(3,4-dimethoxyphenyl)-3-acetoxy-2,10,11,12-tetramethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 47539-89-9 5,6,7-trimethoxy-1-(3',4'-dimethoxybenzyl)3,4-dihydroisoquinoline 

Relevant academic research and scientific papers

Total synthesis of natural and unnatural lamellarins with saturated and unsaturated D-rings

(Chemical Equation Presented) Twenty-eight natural and unnatural lamellarins with either a saturated or an unsaturated D-ring were synthesized according to our developed synthetic route. The key step involved the Michael addition/ring closure (Mi-RC) of the benzyldihydroisoquinoline and α-nitrocinnamate derivatives, which provided the 2-carboethoxypyrrole intermediates in moderate to good yields (up to 78% yield). Subsequent hydrogenolysis/lactonization furnished lamellarins with a saturated D-ring in excellent yields (up to 93% yield). DDQ oxidation of the saturated lamellarin acetates led directly to the corresponding unsaturated analogues in 54-95% yield. In addition, only two steps in our developed strategy require column chromatography.

Ruthenium dioxide in fluoro acid medium. III. Aplication to the synthesis of aporphinic, homoaporphinic and dibenzazocinic alkaloids. Studies towards the preparation of azafluoranthenic skeleton

Intramolecular oxidative couplings of phenylalkyltetrahydroisoquinoline precursors in aporphinic and homoaporphinic alkaloids by using RuO2,2H2O in fluoro acidic media were performed. A comparative study of our reagent with TTFA has been made with different precursors. The procedure was also extended to the synthesis of one dibenzazocinic alkaloid. Then, we attempted to synthetize the azafluoranthenic ring, using phenolic and non phenolic isoquinoline precursors.