2424-61-5

Basic information

• Product Name: dodecyl hydrogen maleate
• Synonyms: dodecyl hydrogen maleate;Dodecylhydrogenmaleat;(Z)-2-Butenedioic acid hydrogen 1-dodecyl ester;Maleic acid 1-dodecyl ester;Maleic acid hydrogen 1-dodecyl ester;2-Butenedioic acid (2Z)-, 1-dodecyl ester;2-Butenedioic acid (2Z)-, monododecyl ester;Einecs 219-360-7
• CAS NO: 2424-61-5
• Molecular Formula: C₁₆H₂₈O₄
• Molecular Weight: 302.4064
• EINECS: 219-360-7
• Mol File: 2424-61-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 58 °C(Solv: hexane (110-54-3))
• Boiling Point: 404.7°Cat760mmHg
• Flash Point: 137.6°C
• Appearance: /
• Density: 1g/cm³
• Vapor Pressure: 1.1E-07mmHg at 25°C
• Refractive Index: 1.471
• PKA: 2.57±0.25(Predicted)
• CAS DataBase Reference: dodecyl hydrogen maleate(CAS DataBase Reference)
• NIST Chemistry Reference: dodecyl hydrogen maleate(2424-61-5)
• EPA Substance Registry System: dodecyl hydrogen maleate(2424-61-5)

Safety Data

• Hazardous Substances Data: 2424-61-5(Hazardous Substances Data)

Usage

Uses

Dodecyl Hydrogen Maleate is a reagent used in the improvement of mechanical properties of vulcanizates od ntural rubber bands.

InChI:InChI=1/C16H28O4/c1-2-3-4-5-6-7-8-9-10-11-14-20-16(19)13-12-15(17)18/h12-13H,2-11,14H2,1H3,(H,17,18)/b13-12-

Upstream product

• 108-31-6 maleic anhydride 
• 112-53-8 1-dodecyl alcohol 

Relevant articles and documents

Epoxidation of monomaleate with hydrogen peroxide catalyzed by [π-C 5H5N(CH2)15CH3] 3PO4(WO3)4

In the study, epoxidation of dodecanol monomaleate, hexadecanol monomaleate, and octadecanol monomaleate were carried out using [π-C 5H5N(CH2)15CH3] 3PO4(WO3)4 as phase-transfer catalyst with 30% hydrogen peroxide as oxidant. The experimental results showed that [π-C5H5N(CH2)15CH 3]3PO4(WO3)4 had excellent catalytic effect on translating C=C double-bond into an epoxy group and had a good yield rate. The synthesized epoxides of decanol monomaleate, hexadecanol monomaleate, and octadecanol monomaleate have enormous potential application in organic synthesis, and they could be readily transformed into various synthetically useful intermediates or final products in many fields of chemistry.

DRUGS AND COMPOSITIONS FOR OCULAR DELIVERY

New prodrugs of therapeutically active compounds, including oligomeric prodrugs of ethacrynic acid, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy. Also a method for the controlled administration of timolol to a patient in need thereof, such as a human, comprising administering a prodrug of timolol in a microparticle in vivo, wherein the timolol prodrug containing microparticle exhibits in vitro drug release kinetics in an aqueous solution at a pH between 6-8 at body temperature of a substantially consistent release of at least 60% timolol itself by molar ratio to the prodrug of timolol or an intermediate metabolite thereof over at least 100 days.

DRUGS AND COMPOSITIONS FOR THE TREATMENT OF OCULAR DISORDERS

The present invention provides new prodrugs of therapeutically active compounds, including oligomeric prodrugs, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.