24242-67-9Relevant academic research and scientific papers
Regioselective preparation of benzo[b]furans from Phenols and α-Bromoketones
Arias, Leire,Vara, Yosu,Cossio, Fernando P.
experimental part, p. 266 - 275 (2012/02/05)
In this paper, a fully regiocontrolled synthesis of either 2- and 3-substituted benzo[b]furans is described. Direct reaction between phenols and α-bromoacetophenones in the presence of neutral alumina yields 2-substituted benzo[b]furans with complete regiocontrol. When a basic salt such as potassium carbonate is used, the corresponding 2-oxoether is obtained. Cyclization of these latter compounds promoted by neutral alumina yields the corresponding 3-substituted benzo[b]furans. Using the former method, Moracin M and other analogues can be obtained from commercial sources in two preparative steps. DFT calculations provide reasonable reaction paths to understand the formation of 2-substituted benzo[b]furans.
Polysubstituted benzofurans and medicinal applications thereof
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Page/Page column 23, (2011/12/03)
The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processe
