24245-27-0

Basic information

• Product Name: N,N'-diphenylguanidine monohydrochloride
• Synonyms: N,N'-diphenylguanidine monohydrochloride;1,3-diphenyl-guanidin monohydrochloride;diphenylguanidine hydrochloride;diphenylguanidinium chloride;n,n'-diphenyl-guanidin monohydrochloride
• CAS NO: 24245-27-0
• Molecular Formula: C₁₃H₁₃N₃*ClH
• Molecular Weight: 247.72336
• EINECS: 246-107-8
• Mol File: 24245-27-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 141-142 °C
• Appearance: /
• Density: 1.19[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• Water Solubility: 16.71g/L at 20℃
• CAS DataBase Reference: N,N'-diphenylguanidine monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-diphenylguanidine monohydrochloride(24245-27-0)
• EPA Substance Registry System: N,N'-diphenylguanidine monohydrochloride(24245-27-0)

Safety Data

• Hazardous Substances Data: 24245-27-0(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

Upstream product

• 142-04-1 aniline hydrochloride 
• 103-72-0 phenyl isothiocyanate 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

'One-flask' transformation of isocyanates and isothiocyanates to guanidines hydrochloride by using sodium bis(trimethylsilyl)amide

A 'one-flask' synthesis of guanidines was developed by reacting isocyanates and isothiocyanates with sodium bis(trimethylsilyl)amide followed by addition of primary or secondary amines with a catalytic amount of AlCl3. The desired guanidines were obtained in good yields and the reaction was applicable to aliphatic and aromatic substrates. A plausible mechanism was proposed through the generation of cyanamide anion from isocyanates or isothiocyanates with sodium bis(trimethylsilyl)amide. Addition of amines and catalytic amount of AlCl3 smoothly converted the cyanamides to the desired guanidines.