242474-46-0Relevant academic research and scientific papers
A simple and versatile route to novel conjugated β-enaminonitriles and their application for the highly regioselective synthesis of nicotinonitriles using a Vilsmeier-type reagent
Katritzky, Alan R.,Denisenko, Anna,Arend, Michael
, p. 6076 - 6079 (2007/10/03)
A straightforward synthesis of conjugated β-enaminonitriles from ketones and β-aminocrotononitrile mediated by TiCl4 is described. The reaction of these novel dienamines with a Vilsmeier-type reagent provides a mild and highly regioselective route for the preparation of nicotinonitriles.
