2426-94-0

Usage

Uses

Used in Pharmaceutical Industry:
4,4'-Bipyrimidine is used as a synthetic intermediate for the preparation of electrophile-substituted pyrazine, pyridazine, pyrimidine, and quinoxaline derivatives. These heterocyclic compounds are of significant interest in the pharmaceutical industry due to their diverse range of biological activities, including potential applications in the development of new drugs for the treatment of various diseases.
Used in Chemical Research:
In the field of chemical research, 4,4'-bipyrimidine is utilized as a starting material for the synthesis of various complex organic molecules. Its unique structure allows for the exploration of novel chemical reactions and the development of innovative synthetic strategies, contributing to the advancement of organic chemistry.
Used in Material Science:
The electrophile-substituted derivatives of 4,4'-bipyrimidine can also find applications in material science, particularly in the development of new materials with unique properties. These materials may have potential uses in various industries, such as electronics, energy storage, and advanced coatings.

Upstream product

• 289-95-2 PYRIMIDINE 
• 109-09-1 2-chloropyridine 
• 1079-66-9 chloro-diphenylphosphine 

Downstream Products

• 795305-22-5 bromo-4,4'-bipyrimidinemesitylnickel(II) 
• 144473-93-8 (4,4'-bipyrimidine)bis(triphenylphosphine)copper(I) tetrafluoroborate 

Relevant academic research and scientific papers

Deprotonative metalation of substituted benzenes and heteroaromatics using amino/alkyl mixed lithium-zinc combinations

Different homoleptic and heteroleptic lithium-zinc combinations were prepared, and structural elements obtained on the basis of NMR spectroscopic experiments and DFT calculations. In light of their ability to metalate anisole, pathways were proposed to justify the synergy observed for some mixtures. The best basic mixtures were obtained either by combining ZnCl 2·TMEDA (TMEDA = N,N,N',N'tetramethylethylenediamine) with [Li(tmp)] (tmp = 2,2,6,6-tetramethylpiperidino; 3 equiv) or by replacing one of the tmp in the precedent mixture with an alkyl group. The reactivity of the aromatic lithium zincates supposedly formed was next studied, and proved to be substrate-, base-, and electrophile-dependent. The aromatic lithium zincates were finally involved in palladium-catalyzed cross-coupling reactions with aromatic chlorides and bromides.

Lithium-mediated zincation of pyrazine, pyridazine, pyrimidine, and quinoxaline

(Chemical Equation Presented) Deprotonation of pyrazine, pyridazine, pyrimidine, and quinoxaline using an in situ mixture of ZnCl2· TMEDA (0.5 equiv) and LiTMP (1.5 equiv) was studied. Pyrazine and pyrimidine were deprotonated in THF at room te