24261-66-3

Basic information

• Product Name: 3-(benzylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride (1:1)
• Synonyms: 1-propanone, 1-(4-methoxyphenyl)-3-[(phenylmethyl)amino]-, hydrochloride (1:1); 3-(Benzylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride (1:1)
• CAS NO: 24261-66-3
• Molecular Formula: C₁₇H₁₉NO₂*ClH
• Molecular Weight: 305.7992
• Mol File: 24261-66-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 430.2°C at 760 mmHg
• Flash Point: 214°C
• Vapor Pressure: 1.32E-07mmHg at 25°C
• CAS DataBase Reference: 3-(benzylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(benzylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride (1:1)(24261-66-3)
• EPA Substance Registry System: 3-(benzylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride (1:1)(24261-66-3)

Safety Data

• Hazardous Substances Data: 24261-66-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 100-46-9 benzylamine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 71371-92-1 N-Benzyl-N-[3-(4-methoxy-phenyl)-3-oxo-propyl]-benzamide 

Relevant articles and documents

Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex (RuPHOX-Ru): The Synthesis of γ-Secondary Amino Alcohols

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of β-secondary amino ketones, directly affording the corresponding chiral γ-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with β-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.