24264-33-3

Basic information

• Product Name: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER
• Synonyms: BUTTPARK 136\48-92;AKOS USSH-4110752;2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER;diethyl 2-amino-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate;A2042/0085820;BAS 00832137;BIM-0027672.P001;CBMicro_027780
• CAS NO: 24264-33-3
• Molecular Formula: C₁₃H₁₈N₂O₄S
• Molecular Weight: 298.36
• Mol File: 24264-33-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 146-148°C
• Appearance: /
• CAS DataBase Reference: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER(24264-33-3)
• EPA Substance Registry System: 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER(24264-33-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 24264-33-3(Hazardous Substances Data)

Usage

General Description

2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER is a chemical compound that belongs to the class of esters. It is a derivative of the amino acid thieno[2,3-c]pyridine-3,6-dicarboxylic acid, and contains two ethyl ester groups. 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRIDINE-3,6-DICARBOXYLIC ACID 3,6-DIETHYL ESTER is used in pharmaceutical research and drug development, particularly in the study of thieno[2,3-c]pyridine derivatives as potential therapeutic agents. It has potential application in the treatment of various diseases and disorders, and its properties are under investigation for potential pharmacological activity.

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 853896-66-9 2-(3-benzoylaminothioureido)-3-carbethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyrido-6-carboxylic acid ethyl ester 
• 953963-29-6 diethyl 2-(2-(3-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 1351512-14-5 diethyl 2-(2-(2-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 920427-26-5 diethyl-2-(2-iodobenzamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 314043-08-8 diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 919754-93-1 diethyl 2-(2-(4-(methylsulfonyl)phenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 864926-75-0 diethyl 2-(3-phenylpropanamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 328540-77-8 diethyl 2-benzamido-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 1351512-12-3 diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 404000-65-3 C₂₀H₂₂N₂O₄S 
• 453511-36-9 ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate 
• 853896-72-7 2-[(N-benzoylhydrazinomethylene)amino]-3-carbethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyrido-6-carboxylic acid ethyl ester 
• 853896-57-8 3-benzoylamino-1,2,3,4,5,6,7,8-octahydro-4-oxo-2-thioxopyrido[4',3',4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid ethyl ester 
• 538370-01-3 diethyl 2({[(benzoyl)amino]carbothioyl}amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylate 

Relevant articles and documents

Ligand- and structure-based in silico studies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents

Kinesin spindle protein (KSP) belongs to the kinesin superfamily of microtubule-based motor proteins. KSP is responsible for the establishment of the bipolar mitotic spindle which mediates cell division. Inhibition of KSP expedites the blockade of the normal cell cycle during mitosis through the generation of monoastral MT arrays that finally cause apoptotic cell death. As KSP is highly expressed in proliferating/cancer cells, it has gained considerable attention as a potential drug target for cancer chemotherapy. Therefore, this study envisaged to design novel KSP inhibitors by employing computational techniques/tools such as pharmacophore modelling, virtual database screening, molecular docking and molecular dynamics. Initially, the pharmacophore models were generated from the data-set of highly potent KSP inhibitors and the pharmacophore models were validated against in house test set ligands. The validated pharmacophore model was then taken for database screening (Maybridge and ChemBridge) to yield hits, which were further filtered for their drug-likeliness. The potential hits retrieved from virtual database screening were docked using CDOCKER to identify the ligand binding landscape. The top-ranked hits obtained from molecular docking were progressed to molecular dynamics (AMBER) simulations to deduce the ligand binding affinity. This study identified MB-41570 and CB-10358 as potential hits and evaluated these experimentally using in vitro KSP ATPase inhibition assays.

Facile assembly of two 6-membered fused N-heterocyclic rings: A rapid access to novel small molecules via Cu-mediated reaction

A rapid, versatile and one-pot Cu-mediated domino reaction has been developed for facile assembly of two six membered fused N-heterocyclic rings leading to novel small molecules as potential inhibitors of PDE4. The Royal Society of Chemistry.