24265-21-2

Usage

InChI:InChI=1/C5H7ClO/c6-5-1-3-7-4-2-5/h1H,2-4H2

Upstream product

• 1708-29-8 2,5-dihydrofuran 
• 188975-30-6 5,6-dihydro-4-trifluoromethylsulfonyloxy-2H-pyran 
• 141534-86-3 (dihydro-2H-pyran-4(3H)-ylidene)hydrazine 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 

Downstream Products

• 623931-31-7 6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-amine hydrochloride 

Relevant academic research and scientific papers

Nickel-Catalyzed Conversion of Enol Triflates into Alkenyl Halides

A Ni-catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench-stable Ni(OAc)2?4 H2O as a precatalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either 1,5-cyclooctadiene or 4-(N,N-dimethylamino)pyridine.

Preparation method of heteroatom-containing cyclohexene halide

The invention discloses a preparation method of a heteroatom-containing cyclohexene halide, belonging to the field of synthesis of fine chemical intermediates. According to the preparation method, cyclohexanone containing heteroatoms is used as a raw material, and gem-dihalide or alkenyl halide is mainly generated in a halogenating reagent; and after an additive is added into organic alkali, and hydrogen halide is removed to generate cyclohexene halide containing heteroatoms. The method is simple in process; the operation of purifying a mixture in traditional methods is avoided; and a productis fully utilized. Under close-to-elimination condition of gem-dibromide, an additive is added to overcome the problem of difficulties in gem-dichloride elimination is by adding, and the purpose of controlling regioselectivity is achieved through steric hindrance of different alkalis.

A synthetic 4- the position is mixed atom substituted cyclohexenyl halo process of the

The invention relates to a method for synthesizing organic compounds, in particular to a process method for synthesizing 4-site heteroatom-substituted cyclohexenyl halide. The method comprises the following steps of: performing refluxing reaction on 4-sit

Rate coefficients for the gas-phase reactions of chlorine atoms with cyclic ethers at 298 K

Rate coefficients of reactions of Cl atoms with cyclic ethers, tetrahydropyran (THP), tetrahydrofuran (THF), and dihydrofurans (2,5-DHF and 2,3-DHF) have been measured at 298 K using a relative rate method. The relative rate ratios for THP and THF are 0.80 ± 0.05 and 0.80 ± 0.08, respectively, with n-hexane as the reference molecule. The relative rate ratios for THF and 2,5-DHF with n-pentane as the reference molecule are 0.95 ± 0.07 and 1.73 ± 0.06, respectively, and for 2,5-DHF with 1-butene as reference is 1.38 ± 0.05. The average values of the rate coefficients are (2.52 ± 0.36), (2.50 ± 0.39), and (4.48 ± 0.59) × 10-10 cm3 molecule-1 s-1 for THP, THF, and 2,5-DHF, respectively. The errors quoted here for relative rate ratios are 2σ of the statistical variation in different sets of experiments. These errors, combined with the reported errors of the reference rate coefficients using the statistical error propagation equation, are the quoted errors for the rate coefficients. In the case of 2,3-DHF, after correcting for the dark reaction with CH3COCl and assuming no interference from other radical reactions, a relative rate ratio of 0.85 ± 0.16 is obtained with respect to cycloheptene, corresponding to a rate coefficient of (4.52 ± 0.99) × 10-10 cm3 molecule-1 s-1. Unlike cyclic hydrocarbons, there is no increase with increasing number of CH2 groups in these cyclic ethers whereas there is an increase in the rate coefficient with unsaturation in the ring. An attempt is also made to correlate the rate coefficients of cyclic hydrocarbons and ethers with the molecular size as well as HOMO energy.

HETEROTRICYCLYL 6-ALKYLIDENE-PENEMS AS ΒΕΤΑ-LACTAMASE INHIBITORS

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.