24275-95-4

Usage

Uses

Used in Pharmaceutical Industry:
10-(4-bromophenyl)-9(10H)-acridinon is used as a pharmaceutical compound for its demonstrated anticancer, antiviral, and antimicrobial properties. Its ability to target and inhibit the growth of cancer cells, as well as its potential to combat viral and microbial infections, makes it a valuable asset in the development of new therapeutic agents.
Used in Bioimaging Applications:
In the field of bioimaging, 10-(4-bromophenyl)-9(10H)-acridinon serves as a fluorescent dye. Its fluorescent properties allow for the visualization and tracking of cellular processes, making it an essential tool in research and diagnostics. This application aids in understanding the compound's interaction with biological systems and its potential use in medical imaging techniques.
Used in Drug Development Research:
10-(4-bromophenyl)-9(10H)-acridinon is utilized as a research compound in drug development. Its unique structure and biological activities provide a foundation for the design and synthesis of new drugs targeting various diseases. 10-(4-bromophenyl)-9(10H)-acridinon's potential in this area is further supported by ongoing research aimed at uncovering its mechanisms of action and optimizing its therapeutic potential.
Used in Medical Diagnostics:
In the medical diagnostics field, 10-(4-bromophenyl)-9(10H)-acridinon is employed for its fluorescent properties, which can be harnessed to develop diagnostic tools and techniques. Its ability to bind to specific biological targets and emit fluorescence can be utilized in the detection and monitoring of diseases, as well as in the assessment of treatment efficacy.

Upstream product

• 5467-74-3 4-Bromophenylboronic acid 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 106-37-6 1.4-dibromobenzene 
• 578-95-0 10H-acridin-9-one 
• 1408293-69-5 {2-[(4-bromophenyl)amino]phenyl}(phenyl)methanone 

Relevant academic research and scientific papers

Compound for organic luminescence and application thereof

The invention relates to a compound for organic luminescence. The structure of the compound is shown as a formula (I) in the description, wherein X is selected from one of carbonyl, oxygen atom or sulfur atom; and the formula (I) is also connected with a

Copper-catalyzed synthesis of N-aryl acridones from 2-amino benzophenones and aryl boronic acids via sequential double oxidative C–N coupling

Pot-economic synthesis of N-aryl acridones was performed with 2-aminobenzophenones and aryl boronic acids as starting materials. Cu-catalyzed chelation-assisted oxidative C–N cross-coupling reactions were well merged with the following intra-molecular oxidative dehydrogenative C–H amination reactions under an air atmosphere. The use of reagent capsules can further resolve the compatibility problem of reagents and simplify the operational process, providing a more straightforward access to the target products.

Mechanochromism, Twisted/Folded Structure Determination, and Derivatization of (N-Phenylfluorenylidene)acridane

(N-Phenylfluorenylidene)acridane (Ph-FA) compounds with electron-withdrawing and -donating substituents (H, MeO, Ph, NO2, Br, F) at the para position of the phenyl group were successfully synthesized by Barton–Kellogg reactions of N-aryl thioacridones and diazofluorene. By using the substituent on the nitrogen atom to alter the electronic properties, both the folded and twisted conformers of p-NO2-C6H4-FA could be crystallographically characterized, which enabled the charge transfer from the electron-donating acridane moiety to the electron-accepting fluorenylidene moiety to be understood. Ground-state mechanochromism, thermochromism, vapochromism, and proton-induced chromism were demonstrated between the folded and twisted conformations of the conformers. Protonation and chemical oxidation of Ph-FA gave two stable acridinium compounds, namely, the fluorenylacridinium and acridinium radical cations. The present study will contribute to the development of functional dyes and organic semiconductors.

Copper-catalyzed intramolecular oxidative C-H functionalization and C-N formation of 2-aminobenzophenones: Unusual pseudo-1,2-shift of the substituent on the aryl ring

A good move: A copper-catalyzed intramolecular oxidative C-H functionalization of 2-aminobenzophenone affords two regioisomeric acridones (see scheme). The reaction involves an unusual pseudo-1,2-migration of R 2 group(s) on the arene ring (bpy=2,2-bipyridine, DMAc=dimethylacetimide). Copyright

Copper-catalyzed intramolecular direct amination of sp2 C-H bonds for the synthesis of N-aryl acridones

A copper-catalyzed approach for the synthesis of N-aryl acridones via sp2 C-H bond amination using air as oxidant under neutral conditions is disclosed. This reaction not only provides a complementary method for synthesizing medicinally important acridones, but also offers a new strategy for sp2 C-H bond amination.