2428-22-0Relevant academic research and scientific papers
Cyclopentadienyl-Based Anticancer Drugs: Improvement of Cytotoxic Activity through Functionalisation of the π Ligand
Absolonová, Monika,Melounková, Lucie,Vinklárek, Jaromír,Honzí?ek, Jan,Dostál, Libor,Mrózek, Ond?ej
, p. 1804 - 1812 (2021)
Cytotoxic complexes containing molybdenum are widely studied as a potential substitution for commercially used drugs that often suffer from pronounced side effects and cellular resistance. Compounds of the type [(η5-Cp′)Mo(CO)2(
Ring-functionalized niobocene complexes
Honzickova, Iva,Honzicek, Jan,Vinklarek, Jaromir,Padelkova, Zdenka,Rezacova, Martina,Sebestova, Lucie
, p. 252 - 258 (2014/04/03)
A series of new ring-functionalized niobocene dichloride compounds (RCH2C5H4)2NbCl2 (R = MeOCH2, (CH2)5NCH2, 2-MeOC 6H4, 3-MeOC6
Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives
Sirignano, Esther,Saturnino, Carmela,Botta, Antonio,Sinicropi, Maria Stefania,Caruso, Anna,Pisano, Assunta,Lappano, Rosamaria,Maggiolini, Marcello,Longo, Pasquale
, p. 3458 - 3462 (2013/06/27)
A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. The capability of some of these compound to elicit relevant repressive effects on cancer cell growth could be taken into account towards novel pharmacological approaches in cancer therapy.
An efficient catalytic method for fulvene synthesis
Cokun, Necdet,Erden, Ihsan
experimental part, p. 8607 - 8614 (2011/11/30)
The effects of the nature and amount of base, substrate structure, amount of added water and solvent on the condensation of carbonyl compounds with cyclopentadiene in the presence of secondary amines were investigated. Based on these studies, a new efficient and green synthesis of fulvenes was developed.
Novel titanocene anti-cancer drugs derived from fulvenes and titanium dichloride
Tacke, Matthias,Allen, Lorcan T.,Cuffe, Laurence,Gallagher, William M.,Lou, Ying,Mendoza, Oscar,Müller-Bunz, Helge,Rehmann, Franz-Josef K.,Sweeney, Nigel
, p. 2242 - 2249 (2007/10/03)
Starting from 6-(p-N,N-dimethylanilinyl)fulvene (1a) or 6-(pentamethylphenyl)fulvene (1b) [1,2-di(cyclopentadienyl)-1,2-di (p-N,N-dimethylaminophenyl)ethanediyl] titanium dichloride (2a) and [1,2-di(cyclopentadienyl)-1,2-bis(pentamethylphenyl)ethanediyl] titanium dichloride (2b) and their corresponding dithiocyanato complexes (3a, 3b) were synthesized. Titanocene 2b did not show a cytotoxic effect, but when 2a was tested against pig kidney carcinoma cells (LLC-PK) or human ovarian carcinoma cells (A2780/cp70) inhibitory concentrations (IC50) of 2.7 × 10-4 and 1.9 × 10-4 M, respectively, were observed.
Facile synthesis of 1,2-diaryl- and triarylethenes with supported fluoride bases
Hellwinkel,Goke,Karle
, p. 973 - 978 (2007/10/02)
Differently substituted arenecarbaldehydes, mainly benzaldehydes, can be very efficiently condensed with a wide variety of methylbenzenes having an electron-withdrawing group in the para-position, as well as with fluorenes, xanthene, cyclopentadienes and indenes by using a standardized KF- or CsF-Al2O3 base system in dimethylformamide.
