24298-26-8

Basic information

• Product Name: 3-(2-hydroxyethoxy)propiononitrile
• Synonyms: 3-(2-hydroxyethoxy)propiononitrile;Einecs 246-137-1
• CAS NO: 24298-26-8
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13046
• EINECS: 246-137-1
• Mol File: 24298-26-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 278.2°Cat760mmHg
• Flash Point: 122.1°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.000528mmHg at 25°C
• Refractive Index: 1.437
• PKA: 14.29±0.10(Predicted)
• CAS DataBase Reference: 3-(2-hydroxyethoxy)propiononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxyethoxy)propiononitrile(24298-26-8)
• EPA Substance Registry System: 3-(2-hydroxyethoxy)propiononitrile(24298-26-8)

Safety Data

• Hazardous Substances Data: 24298-26-8(Hazardous Substances Data)

Usage

General Description

3-(2-hydroxyethoxy)propiononitrile, also known as HEPA, is a chemical compound used as a component in the production of flame retardants, plasticizers, and pharmaceuticals. It is a clear, colorless liquid with a faint odor, and is soluble in water and organic solvents. HEPA is primarily used as a monomer in the production of polymeric materials, and is also employed as an intermediate in the synthesis of various compounds. It is considered to have low acute toxicity, although prolonged exposure to high concentrations may cause irritation to the eyes, skin, and respiratory system. Additionally, HEPA has been identified as a potential sensitizing agent and should be handled with care in industrial and pharmaceutical settings.

InChI:InChI=1/C5H9NO2/c6-2-1-4-8-5-3-7/h7H,1,3-5H2

Upstream product

• 107-21-1 ethylene glycol 
• 107-13-1 acrylonitrile 
• 542-76-7 3-Chloropropionitrile 

Downstream Products

• 99513-01-6 2-(3-aminopropoxy)ethan-1-ol 
• 912849-70-8 toluene-4-sulfonic acid 2-(3-tert-butoxycarbonylamino-propoxy)-ethyl ester 
• 912849-75-3 tert-butyl (3-(2-aminoethoxy)propyl)carbamate 
• 7790-03-6 3-(2-acryloyloxy-ethoxy)-propionitrile 

Relevant articles and documents

Target protein degradation inducing compound, preparation method thereof and pharmaceutical composition for preventing or treating targeted protein related diseases containing the same as an active ingredient

The present invention relates to a degraducer for inducing the decomposition of target protein, a producing method thereof, and a pharmaceutical composition for preventing or treating target protein-related diseases by containing the degraducer as an active ingredient. A novel compound represented by chemical formula 1, ULB-L-PTM, by the present invention, as a degraducer compound inducing the decomposition of target protein using cereblon E3 ubiquitin ligase, is able to significantly achieve a target protein degradation-inducing activity with an excellent binding activity of a cereblon E3 ubiquitin ligase binder thereby, being able to achieve an excellent protein degradation activity by targeting protein or polypeptide related to various diseases. The bromodomain-containing pharmaceutical composition for preventing or treating protein-related diseases or conditions contains the novel compound represented by chemical formula 1 as an active ingredient and has a useful effect of providing a health functional food composition for prevention or improvement.(AA) Example 22 (nM, 24h)COPYRIGHT KIPO 2020

AMINO SULFONYL COMPOUNDS

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

SYNTHESIS AND TRANSFORMATION OF OXYGEN-CONTAINING MONO- AND DINITRILES. I. REACTION OF β-CHLOROPROPIONITRILES WITH DIOLS

In the reaction of β-chloropropionitrile with diols 7-11-membered oxygen-containing mono- and dinitriles were synthesized in ratios of 3:2 respectively, irrespective of the ratio of the initial components.Alkaline hydrolysis of oxygen-containing mononitriles with a weak solution of hydrogen peroxide leads to the formation of the corresponding amides, while alkaline hydrolysis of the oxygen-containing dinitriles leads to two products (amidonitriles and diamides).