243121-07-5Relevant academic research and scientific papers
PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
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Page/Page column 84; 85, (2018/05/16)
The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.
Michael addition of organocopper species to 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones
Yamazaki, Takashi,Shinohara, Noriyasu,Kitazume, Tomoya,Sato, Shoichi
, p. 91 - 96 (2007/10/03)
Investigation of Michael addition has been carried out using versatile organomagnesium or -lithium reagents in the presence of copper(I) species towards chiral 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones, and it was demonstrated that this route enabled us to successfully construct optically active molecules with a CF3 moiety at the chiral center in good yields as well as the high level of diastereofacial selectivity.
