243121-08-6

Upstream product

• 115630-80-3 (E)-3-(trifluoromethyl)propenoic acid chloride 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 

Downstream Products

• 1213238-97-1 C₁₈H₁₇F₃N₂O₃ 
• 1213238-98-2 C₁₈H₁₇F₃N₂O₃ 
• 627881-97-4 (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-3-phenyl-propionic acid tert-butyl ester 
• 288577-23-1 (R)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-propionic acid methyl ester 
• 288577-27-5 (S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-propionic acid methyl ester 

Relevant academic research and scientific papers

Michael addition of organocopper species to 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones

Investigation of Michael addition has been carried out using versatile organomagnesium or -lithium reagents in the presence of copper(I) species towards chiral 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones, and it was demonstrated that this route enabled us to successfully construct optically active molecules with a CF3 moiety at the chiral center in good yields as well as the high level of diastereofacial selectivity.

Novel highly potent, structurally simple γ-trifluoromethyl γ-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3)

The γ-trifluoromethyl γ-sulfone hydroxamate 1 was synthesized both in racemic and enantiomerically pure forms by means of a thia-Michael reaction of p-methoxythiophenol on achiral and chiral 3,3,3-trifluorocrotonoyl Michael acceptors. The (R)-1 enantiomer

2-OXAZOLIDINONES AND THEIR USE AS INHIBITORS OF ANIMAL CELL MOTILITY AND GROWTH

Cell motility and growth inhibitors, including compounds of the general structural formula (I), and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts, pro-drugs, and solvates thereof, as therapeutic agents, are disclosed.