243121-10-0Relevant academic research and scientific papers
The effect of fluoromethyl groups on the diastereoselectivity in the electrophilic alkylation
Tamura, Kenji,Yamazaki, Takashi,Kitazume, Tomoya,Kubota, Toshio
, p. 918 - 930 (2007/10/03)
The effect of fluoromethyl groups on the diastereoselectivity in the electrophilic alkylation is described. In particular, the electrophilic alkylation of enolates with a trifluoromethyl group was proceeded with highly diastereofacial selectivity based on the steric and/or electrostatic effect of substituent with strong electron withdrawing.
Michael addition of organocopper species to 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones
Yamazaki, Takashi,Shinohara, Noriyasu,Kitazume, Tomoya,Sato, Shoichi
, p. 91 - 96 (2007/10/03)
Investigation of Michael addition has been carried out using versatile organomagnesium or -lithium reagents in the presence of copper(I) species towards chiral 3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-ones, and it was demonstrated that this route enabled us to successfully construct optically active molecules with a CF3 moiety at the chiral center in good yields as well as the high level of diastereofacial selectivity.
