243128-37-2

Basic information

• Product Name: 4-Fluoro-3-methoxybenzonitrile
• Synonyms: BUTTPARK 22\01-64;4-FLUORO-3-METHOXYBENZONITRILE;3-Methoxy-4-Fluorobenzonitrile;Benzonitrile, 4-fluoro-3-methoxy- (9CI);4-Fluoro-3-methoxybenzonitrile 99%;4-Fluoro-3-methoxybenzonitrile99%;5-Cyano-2-fluoroanisole, 5-Cyano-2-fluorophenyl methyl ether;5-Cyano-2-fluoroanisole
• CAS NO: 243128-37-2
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• EINECS: -0
• Product Categories: HALIDE;blocks;Carboxes;FluoroCompounds;Nitrile;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Nitriles
• Mol File: 243128-37-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 109 °C
• Boiling Point: 96-98°C 1,5mm
• Flash Point: 96-98°C/1.5mm
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.000506mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Toluene
• BRN: 2965042
• CAS DataBase Reference: 4-Fluoro-3-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-methoxybenzonitrile(243128-37-2)
• EPA Substance Registry System: 4-Fluoro-3-methoxybenzonitrile(243128-37-2)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39-36/37-9
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 243128-37-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C12H16ClFN2/c13-11-3-1-4-12(14)10(11)9-16-7-2-5-15-6-8-16/h1,3-4,15H,2,5-9H2

Upstream product

• 186590-04-5 4-fluoro-3-hydroxy benzonitrile 
• 74-88-4 methyl iodide 
• 946713-86-6 2-(4-fluoro-3-methoxyphenyl)acetic acid 

Downstream Products

• 473416-64-7 4-fluoro-3-[(3-fluorophenyl)-hydroxymethyl]-5-methoxybenzonitrile 
• 1243204-92-3 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzonitrile 
• 1092657-05-0 C₈H₇FN₄O 
• 385784-89-4 2-amino-5-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]benzonitrile 
• 870959-64-1 N-(4-chloro-2,5-dimethoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine 
• 870959-65-2 2-chloro-5-({6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl}amino)benzo-1,4-quinone 

Relevant articles and documents

6-MEMBERED URACIL ISOSTERES

Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Copper-catalyzed decarboxylative C≡N triple bond formation: Direct synthesis of benzonitriles from phenylacetic acids under O2 atmosphere

A copper-catalyzed reaction of phenylacetic acids with urea was found to afford benzonitriles under an oxygen atmosphere. This reaction proceeds smoothly by a sequence of decarboxylation, dioxygen activation, C-H bond functionalization, and nitrile formation with urea as the nitrogen source. Molecular oxygen was found to play a crucial role in this transformation. This reaction represents a novel protocol for the formation of benzonitriles in an environmental friendly way and with good functional group tolerability.

CYCLIC AMINE COMPOUND

A compound represented by the formula (I) or a salt thereof: (I) wherein the ring A represents a 5- to 8-membered ring which may have additional substituent besides R6, R7 and R8; R1 represents an electron-attracting group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom; R6 represents a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom, and R7 represents a cyano group, a nitro group, an acyl group which may have a substituent, a carboxyl group which may be esterified or amidated, or a hydrocarbon group which may have a substituent, or R6 and R7 together with a carbon atom to which they are attached may form a ring which may have a substituent; and R8 represents a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through an oxygen atom, or a group attached through a sulfur atom. The compound or salt has an excellent androgen receptor modulating effect, and is useful for the prevention/treatment of hypogonadism, partial androgen deficiency in aging male, decline in physical strength, cachexia, osteoporosis and the like.