243128-48-5

Usage

Composition

Four carbon atoms, three fluorine atoms, and three bromine atoms

Physical State

Colorless, odorless gas

Primary Uses

Refrigerant and propellant in aerosol products

Boiling Point

Relatively high

Flammability

Non-flammable

Environmental Impact

Potent greenhouse gas, contributes to ozone depletion and global warming

Atmospheric Lifetime

Long

Current Status

Efforts being made to phase out its use and find more sustainable alternatives due to environmental concerns

Advantages

Suitable alternative to traditional refrigerants such as CFCs and HCFCs

Disadvantages

High global warming potential and negative impact on the ozone layer

Upstream product

• 18599-22-9 4-bromo-3,3,4,4-tetrafluorobut-1-ene 

Relevant academic research and scientific papers

Synthesis and Application of Tetrafluoroethylene (CF 2CF 2)-Containing Acetylene Derivatives

On treating 1,3,4-tribromo-1,1,2,2-tetrafluorobutane, readily prepared from commercially available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, with 3.3 equivalents of LHMDS at 0 °C in THF, the corresponding lithium acetylide could be prepared quantitatively. The acetylide reacted well with various aldehydes, ketones, or chlorosilanes to give the corresponding acetylene derivatives in high yields. It was also found that various iodoarenes could participate in the cross-coupling reaction with the zinc acetylide, readily prepared from the lithium acetylide and ZnCl 2·TMEDA complex, in the presence of Pd(PPh 3) 4to bring about the adducts in high yields. Thus-obtained acetylene derivatives underwent smooth Diels-Alder reaction with various 1,3-dienes to afford the corresponding 1,4- or 1,3-cyclohexadiene derivatives. In addition, it was revealed that the oxidative aromatization of the resulting cyclohexadiene derivatives with DDQ took place very smoothly, providing the multi-substituted benzene derivatives having a tetrafluoro ethylene group.

Stereochemically Defined Various Multisubstituted Alkenes Bearing a Tetrafluoroethylene (-CF2CF2-) Fragment

Highly regio- and stereoselective transformation of commercially available 4-bromo-3,3,4,4-tetrafluoro-1-butene into multisubstituted alkenes having a tetrafluoroethylene fragment through Heck reactions and/or Suzuki-Miyaura cross-coupling reactions was established. Thus, the obtained alkenes underwent a smooth reductive coupling reaction with aldehydes under the influence of MeLi/LiBr-free, affording structurally unprecedented fluorinated materials.