243139-93-7Relevant academic research and scientific papers
Synthesis and biological evaluation of 5′-glycyl derivatives of uridine as inhibitors of 1,4-β-galactosyltransferase
Paszkowska, Jadwiga,Kral, Katarzyna,Bieg, Tadeusz,Zaba, Karolina,Wgrzyk, Katarzyna,Jaskowiak, Natalia,Molinaro, Antonio,Silipo, Alba,Wandzik, Ilona
, p. 18 - 25 (2015)
New 5′-glycyl derivatives of uridine containing fragments of varying lipophilicity were synthesized as analogues of natural peptidyl antibiotics. One of the studied compounds, 5′-O-(N-succinylglycyl)-2′,3′-O-isopropylideneuridine (A4), showed moderate inhibition against 1,4-β-galactosyltransferase. However, additional studies showed that the observed inhibitory effect was due to binding to bovine serum albumin, which was used in assays as a stabilizer.
Synthesis of cyclohexane containing 5′-O-Glycine derivatives of uridine as potential inhibitors of UDP-glucuronosyltransferase
Alargov, Dimitar K.,Gugova, Roumyana G.,Denkova, Pavleta S.,Mueller, Gunther,Golovinsky, Evgeny V.
, p. 937 - 943 (2007/10/03)
Summary. In order to design potential inhibitors of UDP-glucuronosyltransferase, two different pathways for the synthesis of cyclohexane containing 5′-O-glycine derivatives of uridine were developed, one starting with the cyclohexyl moiety, and a second o
