Cephalotaxine, a naturally occurring benzazepine alkaloid, is derived from the plant Cephalotaxus harringtonia. It is known for its antiviral, antitumor, and anticancer properties, with its ester derivatives, such as harringotin, sioharringtonine, and homoharringtonine, demonstrating significant activity against various types of leukemia.
24316-81-2
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Basic information
- Product Name: CEPHALOTAXINE
- Synonyms: (-)-CEPHALOTAXINE;CEPHALOTAXINE;Cephalotaxine Labeled d5
- CAS NO:24316-81-2
- Molecular Formula: C21H42O3
- Molecular Weight: 342.56
- EINECS: N/A
- Product Categories: N/A
- Mol File: 24316-81-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: Refrigerator
- Solubility: Chloroform, Methanol
- CAS DataBase Reference: CEPHALOTAXINE(CAS DataBase Reference)
- NIST Chemistry Reference: CEPHALOTAXINE(24316-81-2)
- EPA Substance Registry System: CEPHALOTAXINE(24316-81-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 24316-81-2(Hazardous Substances Data)
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24316-81-2 Usage
Uses
Used in Antiviral Applications:Cephalotaxine is used as an antiviral agent for treating viral infections due to its ability to inhibit viral replication and reduce the severity of the disease.
Used in Antitumor Applications:
Cephalotaxine is used as an antitumor agent, particularly in the treatment of solid malignancies. Its ester derivatives have shown significant activity against experimental P388 leukemia and L-1210 leukemia in mice, making it a promising candidate for cancer treatment.
Used in Antiangiogenic Applications:
Cephalotaxine is used as an antiangiogenic agent for the treatment of angiogenic diseases or for prophylactic treatment to inhibit the onset or progression of such diseases. It helps in preventing the formation of new blood vessels that supply nutrients to the tumor, thereby limiting its growth.
Used in Cellular Proliferative Disease Treatment:
When combined with an antiproliferative agent, cephalotaxine is used for the treatment of cellular proliferative diseases. This combination therapy aims to enhance the effectiveness of treatment and manage the disease more efficiently.
Used in Pharmaceutical Industry:
Cephalotaxine is used in the pharmaceutical industry for the development of new drugs and therapies targeting viral, tumor, and angiogenic diseases. Its unique properties and potential applications make it a valuable compound for research and drug development.
References
[1] R. G. Powell, D. Weisleder, C. R. Smith, Jr. (1972) Antitumor alkaloids from Cephalotaxus harringtonia: Structure and activity, Journal of Pharmaceutical Sciences, 61, 1227-1230 [2] Patent WO 2004009030 A2: Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof [3] Patent US 6734178 B2: Cephalotaxine alkaloid compositions and uses thereofCheck Digit Verification of cas no
The CAS Registry Mumber 24316-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,3,1 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.Calculate Digit Verification of CAS Registry Number 24316-81:
(7*2)+(6*4)+(5*3)+(4*1)+(3*6)+(2*8)+(1*1)=92
92 % 10 = 2
So 24316-81-2 is a valid CAS Registry Number.
24316-81-2Upstream product
24316-81-2Downstream Products
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CEPHALOTAXINE
