24334-20-1

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its potential therapeutic effects. It has been studied for its potential in the treatment of neurological disorders such as Alzheimer's and Parkinson's disease, where it may contribute to the development of new drugs targeting these conditions.
Used in Agrochemical Industry:
1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid is utilized as an important intermediate in the production of agrochemicals, including pesticides and other agricultural chemicals. Its unique chemical structure allows for the creation of compounds that can effectively address pest control and crop protection needs.
Used in Research and Development:
1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid is employed as a research compound in the study of its mutagenic and carcinogenic properties, as well as its role as a neurotransmitter. This research helps to better understand its potential impact on human health and its implications in various neurological disorders.
Used in Toxicological Studies:
Due to its presence in tobacco smoke and grilled foods, 1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid is used in toxicological studies to investigate its potential health risks and effects on human health. This research is essential for developing regulations and guidelines to minimize exposure to harmful substances in these products.

InChI:InChI=1/C8H6N2O2/c11-8(12)6-3-5-1-2-9-4-7(5)10-6/h1-4,10H,(H,11,12)

Upstream product

• 42166-50-7 3-hydrazinopyridine 
• 5832-44-0 3-nitro-4-methylpyridine 
• 24334-18-7 3-(3-nitropyridin-4-yl)-2-oxopropionic acid ethyl ester 
• 24334-19-8 ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate 

Downstream Products

• 40068-76-6 1H-pyrrolo[2,3-c]pyridine-2-carboxamide 
• 867140-61-2 (1H-pyrrolo[2,3-c]pyridin-2-yl)methanamine 
• 1362132-13-5 N-{[4-(piperidine-1-sulfonyl)phenyl]methyl }-1H-pyrrolo[2,3-c]pyridine-2-carboxamide 

Relevant academic research and scientific papers

LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.

Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue

Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4",3":4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA) and four of them exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31 (a renal cancer cell line).

Detailed structure-activity relationship of indolecarboxamides as H 4 receptor ligands

A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable the definition of a predictive QSAR model which identifies several compounds with an activity comparable to 1. A selection of these new H 4R antagonists was synthesized and a comparison of predicted and measured values demonstrates the robustness of the model (47-55). In addition to the H4-receptor activity general CMC and DMPK properties were investigated. Some of the new analogs are not only excellently soluble, but display a significantly increased half-life in mouse liver microsomes as well. These properties qualify these compounds as a possible new standard for future in vivo studies (e.g 51, 52 and 55). Moreover, the current studies also provide valuable information on the potential receptor ligand interactions between the indolcarboxamides and the H4R protein.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.