24338-63-4Relevant academic research and scientific papers
Lophachinins A–E, abietane diterpenes from a Mongolian traditional herbal medicine Lophanthus chinensis
Damdinjav, Davaadagva,Dorjval, Enkhjargal,Itoh, Kohji,Kashiwada, Yoshiki,Kawazoe, Kazuyoshi,Shimomoto, Yusei,Tanaka, Naonobu,Tsuji, Daisuke,Yamada, Kenta
, (2020)
Five new abietane diterpenes, lophachinins A–E (1–5), and eleven known related diterpenes were isolated from a Mongolian traditional herbal medicine, the aerial parts of Lophanthus chinensis (Lamiaceae). The structures of new diterpenes were assigned by spectroscopic analyses. Lophachinins A (1) and B (2) were abietane diterpene possessing an endoperoxy bridge at C-ring. In contrast, lophachinins C–E (3–5) had an abietane skeleton with an aromatized C-ring. The absolute configuration of 1 was elucidated by application of the modified Mosher's method, while those of 2, 3, and 5 were assigned by chemical conversions. The absolute configuration of lophachinin D (4) was deduced by ECD calculation. Anti-inflammatory activity of isolated diterpenes on microglial cells were evaluated.
