243464-39-3

Upstream product

• 243464-46-2 (2S,5R,10S,11R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-12-(4-methoxy-benzyloxy)-11-methyl-2,10-bis-trimethylsilanyloxy-dodec-7-yn-6-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 106731-74-2 tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane 
• 175398-31-9 (S)-6-(tert-butyldiphenylsilyloxy)-5-hydroxyhexanoic acid δ-lactone 
• 243464-45-1 (S)-6-(tert-butyl-diphenylsilyloxy)-hexane-1,5-diol 
• 243464-44-0 (2S)-6-benzyloxy-1-(tert-butyldiphenylsilyloxy)-hex-4-yn-2-ol 

Downstream Products

• 328535-13-3 (2S,6S,8S,11R)-11-(tert-Butyl-dimethyl-silanyloxy)-8-(tert-butyl-diphenyl-silanyloxymethyl)-2-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-4-methyl-1,7-dioxa-spiro[5.5]undec-4-ene 

Relevant academic research and scientific papers

Abbreviated synthesis of the C3-C14 (substituted 1,7-dioxaspiro[5.5]undec-3-ene) system of okadaic acid.

[formula: see text] Described is a novel, concise, and flexible synthesis of the C3-C14 portion of okadaic acid. A substituted valerolactone (C3-C8) was prepared in three steps and alpha-hydroxylated using Davis' oxaziridine. Conjugate addition of dimethy