243472-70-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-5,6-diphenylpyrazine is used as a building block for the synthesis of various biologically active molecules, contributing to the development of new pharmaceutical compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-5,6-diphenylpyrazine serves as a precursor in the synthesis of bioactive molecules, potentially enhancing crop protection and management strategies.
Used in Organic Synthesis:
2-Bromo-5,6-diphenylpyrazine is utilized as an intermediate in organic synthesis for the production of other pyrazine-based compounds, expanding the range of chemical products available for various applications.
Used in Chemical Research and Development:
Its unique structure and properties make 2-Bromo-5,6-diphenylpyrazine a valuable tool in advancing chemical research and development, potentially leading to innovative discoveries and applications.

Upstream product

• 18591-57-6 2,3-Diphenyl-6-hydroxypyrazine 
• 243472-82-4 2,3-diphenyl-5-trimethylsilanyloxy-pyrazine 
• 134-81-6 benzil 
• 18591-57-6 5,6-diphenyl-2-hydroxypyrazine 

Downstream Products

• 110249-96-2 2-(5,6-diphenyl-pyrazin-2-ylamino)-ethanol 
• 81225-12-9 2-cyano-5,6-diphenylpyrazine 
• 111639-67-9 5,6-diphenyl-2,3-dihydro-imidazo[1,2-a]pyrazine 
• 475086-75-0 4-[N-(5,6-diphenylpyrazine-2-yl)-N-isopropylamino]-1-butanol 
• 475085-57-5 MRE-269 
• 475084-96-9 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butyl ester 
• 475086-01-2 Selexipag 

Relevant academic research and scientific papers

Synthesis method of diphenyl pyrazine derivative

The invention discloses a synthesis method of a diphenyl pyrazine derivative. The method is characterized in that benzil and glycinamide are used as raw materials, and a target product is prepared through five-step reaction. The obtained target product is high in purity, subsequent production of high-quality drugs is facilitated, and the synthesis method is reasonable in route design, mild in reaction condition, free of high-temperature reaction, good in safety and high in feasibility.

A preparation method of a diphenyl pyrazine compound

A diphenyl pyrazine compound I having a novel structure is developed according to structures of existing IP receptor agonists and a preparation method of the compound I is provided. The method is simple to operate and high in yield, and the yield of each step is higher than 70% preferably. The compound I can be efficiently prepared by the method. The invention also provides a preparation method ofan intermediate compound X for preparing the compound I, and the method has high yield and high product purity.

Preparation method of 2-bromine-5,6-diphenyl pyrazine

The invention relates to a preparation method of 2-bromine-5,6-diphenyl pyrazine. The preparation method of the 2-bromine-5,6-diphenyl pyrazine comprises the following steps: performing reaction on 5-hydroxyl-2,3-diphenyl pyrazine serving as a starting material, a reaction solvent comprising at least one of benzene, methylbenzene and tetrahydrofuran, and phosphorus oxybromide according to a certain proportion at 65 to 85 DEG C for 1 to 3 hours to prepare 2-bromine-5,6-diphenyl pyrazine, pouring the system slowly into ice water after the reaction, continuously stirring for 20 minutes, adjusting the pH value by using a saturated carbonate solution to be 8.0, performing ethyl acetate extraction, washing with a saturated salt solution, drying with anhydrous sodium sulfate, performing rotary evaporation and concentration to obtain a 2-bromine-5,6-diphenyl pyrazine crude product, and performing recrystallization on the crude product to obtain a pure product. The preparation method of the 2-bromine-5,6-diphenyl pyrazine is mild in reaction condition, high in speed, easy to operate and control and simple in aftertreatment, and the product has stable quality and high purity.

Studies on pyrazines. 35 [1]. An improved synthesis of bromopyrazines from hydroxypyrazines

The synthesis of bromopyrazines from hydroxypyrazines was successfully effected by the procedure via trimethylsilyloxypyrazines, the sequence of which proceeds under mild conditions and does not require the isolation of intermediate.