2435-50-9

Basic information

• Product Name: PYRIMIDINE-4-CARBOXALDEHYDE
• Synonyms: RARECHEM AK ML 0567;PYRIMIDINE-4-CARBOXALDEHYDE;4-Pyrimidinecarboxaldehyde;4-Pyrimidinecarboxaldehyde (7CI,8CI,9CI);4-PYRIMIDINE CARBALDEHYDE;4-Formylpyrimidine, 4-Formyl-1,3-diazine
• CAS NO: 2435-50-9
• Molecular Formula: C₅H₄N₂O
• Molecular Weight: 108.1
• Product Categories: PYRIMIDINE;Pyrimidine series;pharmacetical;Heterocycle-Pyrimidine series
• Mol File: 2435-50-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 225.3 °C at 760 mmHg
• Flash Point: 92.6 °C
• Appearance: /
• Density: 1.234 g/cm³
• Vapor Pressure: 0.0869mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.14±0.10(Predicted)
• CAS DataBase Reference: PYRIMIDINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIMIDINE-4-CARBOXALDEHYDE(2435-50-9)
• EPA Substance Registry System: PYRIMIDINE-4-CARBOXALDEHYDE(2435-50-9)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 2435-50-9(Hazardous Substances Data)

Usage

General Description

Pyrimidine-4-carboxaldehyde, also known as 4-formylpyrimidine, is a chemical compound with the molecular formula C5H4N2O. It is a heteroaromatic aldehyde that contains a pyrimidine ring with a formyl group attached to the fourth position. Pyrimidine-4-carboxaldehyde is commonly used as a building block in organic synthesis and is a precursor for the production of various pharmaceuticals and agrochemicals. It is also utilized in the synthesis of dyes, metal complexes, and other fine chemicals. Pyrimidine-4-carboxaldehyde has potential applications in the pharmaceutical industry due to its versatile reactivity and its ability to serve as a key intermediate in the creation of biologically active compounds.

InChI:InChI=1/C5H4N2O/c8-3-5-1-2-6-4-7-5/h1-4H

Upstream product

• 25746-87-6 acetal dimethylique du pyrimidine-4 carboxaldehyde 
• 49689-16-9 triazolo<1,5-c>pyrimidine 
• 3438-46-8 4-Methylpyrimidine 
• 2941-72-2 6-methoxy-2-methylbenzothiazole 

Downstream Products

• 50305-79-8 (E)-N-(pyrimidin-4-ylmethylidene)hydroxylamine 
• 1467048-13-0 4-(4-tert-butylcyclohexylamino)-3-(pyrimidin-4-ylmethylamino)benzoate 
• 1375752-34-3 (4R,5R)-4-(5-(phenylethynyl)pyridin-3-yl)-5-(pyrimidin-4-yl)oxazolidin-2-one 
• 1375752-33-2 (4S,5S)-4-(5-(phenylethynyl)pyridin-3-yl)-5-(pyrimidin-4-yl)oxazolidin-2-one 

Relevant articles and documents

The chemistry of [1,2,3]triazolo[1,5-c]pyrimidine

Reactions of [1,2,3]triazolo[1,5-c]pyrimidine 2 with some electrophiles and nucleophiles are reported. Triazole ring opening and loss of nitrogen is the principal reaction with electrophiles. With strong acids protonation on N6 competes successfully. Derivatives in which the pyrimidine ring has been opened are obtained in reactions with nucleophiles. No stable simple substitution compounds were found.

ISOXAZOLO-PYRIDAZINE DERIVATIVES

The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the treatment of cognitive disorders like Alzheimer's disease.

6-(SUBSTITUTED)METHYLENE-PENICILLANIC AND 6-(SUBSTITUTED)HYDROXYMETHYL-PENICILLANIC ACIDS AND DERIVATIVES THEREOF

Beta-lactamase inhibiting compounds of the formula: or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X.3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxamido or amidino groups; one or R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2 OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them