2435-50-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyrimidine-4-carboxaldehyde is used as a key intermediate for the production of various pharmaceuticals and agrochemicals. Its versatile reactivity and ability to serve as a precursor for biologically active compounds make it a valuable component in the development of new drugs.
Used in Organic Synthesis:
Pyrimidine-4-carboxaldehyde is used as a building block in organic synthesis, enabling the creation of a wide range of chemical compounds.
Used in Dye Synthesis:
Pyrimidine-4-carboxaldehyde is used as a precursor in the synthesis of dyes, contributing to the development of new colorants for various applications.
Used in Metal Complex Synthesis:
Pyrimidine-4-carboxaldehyde is utilized in the synthesis of metal complexes, which have potential applications in catalysis, materials science, and other fields.

InChI:InChI=1/C5H4N2O/c8-3-5-1-2-6-4-7-5/h1-4H

Upstream product

• 49689-16-9 triazolo<1,5-c>pyrimidine 
• 2941-72-2 6-methoxy-2-methylbenzothiazole 
• 3438-46-8 4-Methylpyrimidine 
• 25746-87-6 acetal dimethylique du pyrimidine-4 carboxaldehyde 

Downstream Products

• 50305-79-8 (E)-N-(pyrimidin-4-ylmethylidene)hydroxylamine 
• 1293396-31-2 4-[4-(4-Fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidine 
• 1293396-37-8 tert-Butyl 4-(4-phenyl-5-pyrimidin-4-yl-1H-imidazol-1-yl)piperidine-1-carboxylate 
• 760211-80-1 4-(4-phenyl-1-piperidin-4-yl-1H-imidazol-5-yl)pyrimidine 
• 1293396-30-1 tert-butyl 4-[4-(4-fluorophenyl)-5-pyrimidin-4-yl-1H-imidazol-1-yl]piperidine-1-carboxylate 
• 1293395-72-8 4-[4-(4-fluorophenyl)-1-{1-[(1R)-1-isoxazol-3-ylethyl]piperidin-4-yl}-1H-imidazol-5-yl]pyrimidine 
• 1293395-73-9 4-[4-(4-fluorophenyl)-1-{1-[(1S)-1-isoxazol-3-ylethyl]piperidin-4-yl}-1H-imidazol-5-yl]pyrimidine 
• 1293396-04-9 4-[4-(4-fluorophenyl)-1-{1-[(5-methylisoxazol-3-yl)methyl]piperidin-4-yl}-1H-imidazol-5-yl]pyrimidine 
• 1293396-44-7 N-[1-(4-fluorophenyl)-2-oxo-2-pyrimidin-4-ylethyl]acetamide 
• 1375752-32-1 (4R,5S)-4-(5-(phenylethynyl)pyridin-3-yl)-5-(pyrimidin-4-yl)oxazolidin-2-one 
• 1375752-31-0 (4S,5R)-4-(5-(phenylethynyl)pyridin-3-yl)-5-(pyrimidin-4-yl)oxazolidin-2-one 
• 1375752-34-3 (4R,5R)-4-(5-(phenylethynyl)pyridin-3-yl)-5-(pyrimidin-4-yl)oxazolidin-2-one 
• 1375752-33-2 (4S,5S)-4-(5-(phenylethynyl)pyridin-3-yl)-5-(pyrimidin-4-yl)oxazolidin-2-one 
• 1467048-13-0 4-(4-tert-butylcyclohexylamino)-3-(pyrimidin-4-ylmethylamino)benzoate 

Relevant academic research and scientific papers

The chemistry of [1,2,3]triazolo[1,5-c]pyrimidine

Reactions of [1,2,3]triazolo[1,5-c]pyrimidine 2 with some electrophiles and nucleophiles are reported. Triazole ring opening and loss of nitrogen is the principal reaction with electrophiles. With strong acids protonation on N6 competes successfully. Derivatives in which the pyrimidine ring has been opened are obtained in reactions with nucleophiles. No stable simple substitution compounds were found.

Novel Compounds As Casein Kinase Inhibitors

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

ISOXAZOLO-PYRIDAZINE DERIVATIVES

The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the treatment of cognitive disorders like Alzheimer's disease.

Facile, one-step production of niacin (vitamin B3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst

Niacin (3-picolinic acid), which is extensively used as vitamin B 3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts witha solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications.

6-(SUBSTITUTED)METHYLENE-PENICILLANIC AND 6-(SUBSTITUTED)HYDROXYMETHYL-PENICILLANIC ACIDS AND DERIVATIVES THEREOF

Beta-lactamase inhibiting compounds of the formula: or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X.3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxamido or amidino groups; one or R2 and R3 is H and the other is as disclosed for the other of R12 and R13, or is Cl or CH2 OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them