24351-56-2

Usage

Uses

Used in Organic Synthesis:
3-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID serves as a building block in the synthesis of other organic compounds. Its presence in the molecular structure allows for the creation of a variety of chemical entities, making it a valuable intermediate in organic chemistry.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID is used as a key component in the development and production of various drugs. Its unique structure contributes to the formulation of new medicinal compounds with potential therapeutic applications.
Used in Agrochemicals:
3-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID is also utilized in the agrochemical sector, where it plays a role in the synthesis of pesticides and other agricultural chemicals. Its chemical properties make it suitable for the development of effective and targeted agrochemicals.
Used in Materials Science:
In the field of materials science, 3-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID is employed in the research and development of new polymers and materials. Its structural features contribute to the creation of innovative materials with specific properties for various applications.
Used in Research and Development:
3-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID is a valuable compound in research settings, where it is used to explore new chemical reactions, mechanisms, and applications. Its unique structure and properties make it an interesting subject for scientific investigation and potential discovery of new uses.

InChI:InChI=1/C14H10O4/c15-14(16)11-3-1-2-9(6-11)10-4-5-12-13(7-10)18-8-17-12/h1-7H,8H2,(H,15,16)

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 

Downstream Products

• 1616609-90-5 3-(benzo[d][1,3]dioxol-5-yl)-N,N-diisopropylbenzamide 

Relevant academic research and scientific papers

Benzimidazole compound, preparation method thereof and application of the benzimidazole compound in preparation of ferroptosis inhibitor

The invention discloses a benzimidazole compound, a preparation method thereof and application of the benzimidazole compound in preparation of a ferroptosis inhibitor. The benzimidazole compound has a structure as shown in a formula (I) or a formula (II)

Efficient modulation of γ-aminobutyric acid type a receptors by piperine derivatives

Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABAAR). We have synthesized a library of 76 piperine analogues and analyzed their effects on GABAAR by means of a two-microelectrode voltage-clamp technique. GABAAR were expressed in Xenopus laevis oocytes. Structure-activity relationships (SARs) were established to identify structural elements essential for efficiency and potency. Efficiency of piperine derivatives was significantly increased by exchanging the piperidine moiety with either N,N-dipropyl, N,N-diisopropyl, N,N-dibutyl, p-methylpiperidine, or N,N-bis(trifluoroethyl) groups. Potency was enhanced by replacing the piperidine moiety by N,N-dibutyl, N,N-diisobutyl, or N,N-bistrifluoroethyl groups. Linker modifications did not substantially enhance the effect on GABAAR. Compound 23 [(2E,4E)-5-(1,3-benzodioxol-5-yl)-N,N-dipropyl-2,4-pentadienamide] induced the strongest modulation of GABAA (maximal GABA-induced chloride current modulation (IGABA-max = 1673% ± 146%, EC 50 = 51.7 ± 9.5 μM), while 25 [(2E,4E)-5-(1,3-benzodioxol- 5-yl)-N,N-dibutyl-2,4-pentadienamide] displayed the highest potency (EC 50 = 13.8 ± 1.8 μM, IGABA-max = 760% ± 47%). Compound 23 induced significantly stronger anxiolysis in mice than piperine and thus may serve as a starting point for developing novel GABA AR modulators.