24353-78-4

Basic information

• Product Name: tetramethylhexanoic acid
• Synonyms: tetramethylhexanoic acid;OJBOWZVSJWNXKS-UHFFFAOYSA-N
• CAS NO: 24353-78-4
• Molecular Formula: C10H20 O2
• Molecular Weight: 172.26
• Mol File: 24353-78-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tetramethylhexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: tetramethylhexanoic acid(24353-78-4)
• EPA Substance Registry System: tetramethylhexanoic acid(24353-78-4)

Safety Data

• Hazardous Substances Data: 24353-78-4(Hazardous Substances Data)

Usage

Uses

2,2,3,5-Tetramethylhexanoic Acid is used in analytical studies as a method to quantitatively determine the total organic acid content in aqueous coolant.

Relevant articles and documents

Hydrophobic cis-platinum complexes efficiently incorporated into liposomes

The present invention concerns a platinum (II) four-coordinant complex having the formula: STR1 wherein R1 is an alkyl diamine or cycloalkyl diamine and R2 and R3 are an alkylcarboxylato containing from five to ten carbon atoms. The R1 is preferably trans-D,L-1,2-diaminocyclohexane, trans-R,R-1,2-diaminocyclohexane, trans-S,S-1,2-diaminocyclohexane, cis-1,2-diaminocyclohexane ethylene diamine or 1,1-bis(aminomethyl)cyclohexane. The R2 and R3 are preferably neohexanoato, neoheptanoato, neononanoato, neodecanoato, neooctanoato, neopentanoato, 2-ethylhexanoato, 2-ehtylbutyrato, 2-propylpropanoato, 2-methyl-2-ethylheptanoato, 2,2-diethylhexanoato, 2,2-dimethyl-4-ethylhexanoato, 2,2-diethyl-4-methylpentanoato, 2,2-dimethyloctanoato, 2-methyl-2-ethylheptanoato, 2,2-diethylhexanoato, 2,2-diethyl-4-methylpentanoato or 2,2,4,4-tetramethylpentanoato. In an important further aspect, the present invention involves preparation and therapeutic use of a liposome comprising a phospholipid and a four-coordinate platinum complex having the formula: STR2 wherein R1 is an alkyl diamine or cycloalkyl diamine and R2 and R3 are an alkylcarboxylato containing from about five to about fourteen carbon atoms. The R1, R2 and R3 functions are preferably as described above with the exception that R2 and R3 may have even longer alkyl chains such as myristate and laurate, i.e., up to fourteen carbon atoms. For therapeutic use, a pharmaceutical composition comprising this liposome and a pharmaceutically acceptable carrier or diluent may be readily prepared by methods well known to those skilled in the art. The liposomes are useful vehicles for solubilizing the otherwise aqueously insoluble complexes of the present invention. The phospholipids of the liposomes may be one or more of phosphatidylglycerol, phosphatidylcholine, sphingomyelin, phosphatidic acid or phosphatidylserine. The liposomes more preferably consist essentially of phosphatidylglycerol, phosphatidylcholine or a combination thereof and may also comprise cholesterol. The liposomes of the present most preferably comprise phospholipid consisting essentially of dimyristoylphosphatidylglycerol, dimyristoylphosphatidylcholine or a combination thereof.