243655-94-9

Basic information

• Product Name: Formamide, N,N'-[(1R,2R,4R)-3,3-dimethylbicyclo[2.2.1]heptane-1,2-diyl]bis-
• CAS NO: 243655-94-9
• Molecular Formula: C11H18N2O2
• Mol File: 243655-94-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Formamide, N,N'-[(1R,2R,4R)-3,3-dimethylbicyclo[2.2.1]heptane-1,2-diyl]bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N,N'-[(1R,2R,4R)-3,3-dimethylbicyclo[2.2.1]heptane-1,2-diyl]bis-(243655-94-9)
• EPA Substance Registry System: Formamide, N,N'-[(1R,2R,4R)-3,3-dimethylbicyclo[2.2.1]heptane-1,2-diyl]bis-(243655-94-9)

Safety Data

• Hazardous Substances Data: 243655-94-9(Hazardous Substances Data)

Upstream product

• 77287-34-4 formamide 
• 154617-20-6 (-)-(1R)-3,3-dimethyl-2-oxo-1-norbornyl triflate 

Downstream Products

• 401929-50-8 (1R,2R)-3,3-dimethyl-1,2-norbornanediamine 

Relevant articles and documents

About the Leuckart reaction of chiral 2-norbornanones bearing electron-withdrawing groups: Reaction of bridgehead triflates and triflamides

The mechanism of the Leuckart reaction of 3,3- and 7,7-dimethyl-2-oxo-1-norbornyl triflates and triflamides, synthesised by us starting from (1R)-camphor and (1R)-fenchone, has been studied. Strikingly, the electron-withdrawing capacity of the bridgehead substituents has demonstrated not to be enough to control the Wagner-Meerwein rearrangement during the course of the reaction, so that only both enantiomers of a 3,3-dimethylnorbornanediamine derivative have been obtained as final products. As a result, the total synthesis of these interesting chiral compounds has been optimised and shortened until three overall steps starting from (1R)-fenchone.