243657-14-9

Basic information

• Product Name: 2-N-bis(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine
• Synonyms: 2-N-bis(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine
• CAS NO: 243657-14-9
• Molecular Weight: 895.753
• Mol File: 243657-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-N-bis(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-N-bis(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine(243657-14-9)
• EPA Substance Registry System: 2-N-bis(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine(243657-14-9)

Safety Data

• Hazardous Substances Data: 243657-14-9(Hazardous Substances Data)

Upstream product

• 129184-64-1 3',5'-bis-O-trimethylsilyl-2'-deoxyguanosine 
• 189216-43-1 2,2'-bis(2-nitrophenyl)ethyl chloroformate 
• 243657-15-0 5',3'-bis(O-tert-butyldimethylsilyl)-6-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine 
• 243657-13-8 2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 
• 51549-35-0 3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine 

Downstream Products

• 961-07-9 2'-Deoxyguanosine 

Relevant articles and documents

Photocleavable protecting groups as nucleobase protections allowed the solid-phase synthesis of base-sensitive SATE-prooligonucleotides

The first synthesis of oligodeoxynucleotide heteropolymers carrying base-sensitive S-pivaloylthioethyl (t-Bu-SATE) phosphotriester linkages has been performed. It is based on the use of 6-nitroveratryloxycarbonyl (NVOC) and 2,2'-bis(2-nitrophenyl)ethoxycarbonyl (diNPEOC) groups as nucleobase protections in combination with photolysis deprotection. The synthesis was realized using the phosphoramidite approach on solid support bearing a 1-(o- nitrophenyl)-1,3-propanediol linker. The removal of the protecting groups and the cleavage of the oligonucleotides from the solid support were accomplished in a single photolysis procedure upon UV irradiation at wavelengths > 300 nm. Faster deprotection rates were observed for diNPEOC-protected nucleosides and oligomers than with NVOC-protected ones. The synthesis of pentanucleoside t- Bu-SATE-phosphotriesters d((5')TpCpCpCpTp(3')), d((5')TpApApApAp(3')), and d((5')TpGpGpGpTp(3')) and of dodecanucleoside t-Bu-SATE-phosphotriesters and -phosphorothioate d((5')ApCpApCpCpCpApApTpTpCpTp(3')) and d((5')ApGpApApTpTpGpGpGpTpGpTp(3')) demonstrated the efficiency of the method.