243669-48-9

Basic information

• Product Name: ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE
• Synonyms: BUTTPARK 29\08-50;ETHYL 5'-AMINO-2,3'-BITHIOPHENE-4'-CARBOXYLATE;ETHYL 2-AMINO-4-(2-THIENYL)-3-THIOPHENECARBOXYLATE;ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE;AKOS BBS-00002564;3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-(2-THIENYL)-, ETHYL ESTER;5'-AMINO-[2,3']BITHIOPHENYL-4'-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2-amino-4-(thien-2-yl)thiophene-3-carboxylate
• CAS NO: 243669-48-9
• Molecular Formula: C₁₁H₁₁NO₂S₂
• Molecular Weight: 253.34
• Mol File: 243669-48-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 85 °C
• Boiling Point: 389.3 °C at 760 mmHg
• Flash Point: 189.2 °C
• Appearance: /
• Density: 1.33 g/cm³
• PKA: -0.39±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE(243669-48-9)
• EPA Substance Registry System: ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE(243669-48-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 243669-48-9(Hazardous Substances Data)

Usage

General Description

ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE is a chemical compound with the molecular formula C11H11NO2S2. It is a heterocyclic compound containing a thiophene ring with an amino group and an ethyl ester group attached to it. ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE has potential applications in medicinal chemistry and drug development due to its unique structural features and biological activities. It may also have uses in organic synthesis and materials science. However, further research and testing are needed to fully understand and utilize the properties and potential applications of ETHYL 2-AMINO-4-(2-THIENYL)THIOPHENE-3-CARBOXYLATE.

Upstream product

• 88-15-3 2-Acetylthiophene 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 243669-51-4 2-benzyl-5-thiophen-2-yl-3H-thieno[2,3-d]pyrimidin-4-one 
• 255378-83-7 2-chloromethyl-5-(2-thienyl)thieno[2,3-d]pyrimidine-4(3H)-one 
• 380645-55-6 ethyl 5'-(4-chlorobenzamido)-2,3'-bithiophene-4'-carboxylate 

Relevant articles and documents

Synthesis of pyridine, pyran and thiazole containing thiophene derivatives and their anti-tumor evaluations

The multi-component reaction of 2-acetylthiophene with aromatic aldehydes and either malononitrile or ethyl cyanoacetate gave the pyran derivatives 4a–4f and pyridine derivatives 5a–5f. On the other hand, the reaction of the 2-acetylthiophene with elemental sulfur and either malononitrile or ethyl cyanoacetate gave the thiophene derivatives 6a and 6b; respectively. Compounds 6a and 6b underwent a series of heterocyclic reactions to give thiazole and thiophene derivatives. All the products were assessed for antitumor activity towards human cancer human gastric cancer (NUGC and HR), human colon cancer (DLD1), human liver cancer (HA22T and HEPG2), human breast cancer (MCF), nasopharyngeal carcinoma (HONE1) cell lines. Compounds 4e, 4f, 5e, 5f, 7b, 8b, 10e, 10f, 11e, 11f, 14d-f, 15d-f, 16a,b and 18b exhibited optimal cytotoxic effect against cancer cell lines, with IC50’s in the nM range. Moreover, 7b, 10e, 14d, 15e and 16b showed no toxicity against shrimp larvae. Anti-proliferative cell activity against cancer cell lines of the most potent compounds showed that compounds 5f and 10e achieved the highest activities among the tested compounds.