2437-61-8

Usage

Solvent in chemical processes

Used as a solvent in various chemical reactions and processes.

Precursor in pharmaceutical production

Serves as a starting material for the synthesis of pharmaceuticals and other synthetic organic compounds.

Anti-cancer properties

Investigated for its potential to combat cancer cells.

Antioxidant properties

Explored for its ability to neutralize harmful free radicals and prevent oxidative damage.

Upstream product

• 141-75-3 butyryl chloride 
• 87-66-1 2-hydroxyresorcinol 
• 107-92-6 butyric acid 
• 106-31-0 butanoic acid anhydride 

Downstream Products

• 14503-28-7 2.3.4-Trihydroxy-1-butyl-benzol 

Relevant academic research and scientific papers

An efficient chemo-enzymatic approach towards variably functionalized benzotropolones

An efficient three-step synthesis for benzotropolones via three catalytic steps is presented. Pyrogallol phenones are formed in the first step starting from pyrogallol, which is acylated by proton-catalysis. Catalytic hydrogenation of the phenones yields the corresponding alkylated pyrogallyl dervatives. In the final enzyme-catalyzed step the pyrogallol derivatives are annulated to form the benzotropolone cores. An alternative pathway via the Pechmann reaction is also presented. The combination of the three catalytic steps gives access to a wide range of benzotropolone congeners.

The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors

Some pyrogallol and catechol derivatives were synthesized, and their urease inhibitory activity was evaluated by using acetohydroxamic acid (AHA), a well known Helicobacter pylori urease inhibitor, as positive control. The assay results indicate that many compounds have showed potential inhibitory activity against H. pylori urease. 4-(4-Hydroxyphenethyl)phen-1,2-diol (2a) was found to be the most potent urease inhibitor with IC50s of 1.5 ± 0.2 μM for extracted fraction and 4.2 ± 0.3 μM for intact cell, at least 10 times and 20 times lower than those of AHA (IC50 of 17.2 ± 0.9 μM, 100.6 ± 13 μM), respectively. This finding indicate that 2a would be a potential urease inhibitor deserves further research. Molecular dockings of 2a into H. pylori urease active site were performed for understanding the good activity observed.

AN ELEGANT SYNTHESIS OF 6-BUTYRYLCHROMANS AND CHROMENES

Condensation of hydroxybutyrophenones viz., 2,3,4-trihydroxy- (1), 2,4-dihydroxy- (3) and 2,4-dihydroxy-3-methyl- (6) butyrophenones with 2-methyl-1,3-butadiene in the presence of orthophosphoric acid affords 6-butyrylchromans which can be dehydrogenated to 6-butyrylchromenes.