24372-52-9Relevant academic research and scientific papers
A facile preparation of trisubstituted amino-furan and -thiophene derivatives
Medimagh, Raouf,Marque, Sylvain,Prim, Damien,Chatti, Saber
, p. 6055 - 6065 (2011)
β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.
Convenient amination of weakly activated thiophenes, furans and selenophenes in aqueous media
Prim, Damien,Kirsch, Gilbert
, p. 6511 - 6526 (2007/10/03)
We describe herein a new amination procedure of weakly activated heterocyclic bromo derivatives in aqueous media. The base catalysed mechanism of this reaction is also confirmed. Moreover, the application of this strategy to the preparation of amino furans and selenophenes is outlined.
