243846-87-9Relevant academic research and scientific papers
Enantioselective synthesis of (S)- and (R)-mappicines and their analogues
Das, Biswanath,Madhusudhan
, p. 7875 - 7880 (1999)
The naturally occurring alkaloids, camptothecin and mappicine ketone were converted to racemic mappicine acetate which was enantioselectively hydrolyzed to (S)- and (R)-mappicines in high optical purity using baker's yeast and a lipase, Amano PS. Treatment of the racemic acetate with baker's yeast afforded (S)-mappicine while with Amano PS yielded (R)-mappicine. 9- Methoxycamptothecin and 9-methoxymappicine ketone underwent similar conversion to (S)- and (R)-9-methxymappicines.
